Authors : Rasaq Olugbenga Fafioye; Ebenezer Idowu Olatubosun Ajayi; Bamidele Stephen Ajilore; Omolola Yinka Adeagbo; Yusuff Adewale Akeem

Volume/Issue : Volume 11 - 2026, Issue 4 - April

Google Scholar : https://tinyurl.com/2hysrjxu

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DOI : https://doi.org/10.38124/ijisrt/26apr2137

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Abstract : Type 2 diabetes mellitus (T2DM) to a large extent amplifies the chance of developing cardiovascular disease (CVD), identified by increased inflammatory indicators like interleukin-6 (IL-6), cardiac indicators such as cardiac troponin I (TnI) and imbalance of lipids (fats) in the blood, such as high LDL (“bad” cholesterol), low HDL (“good” cholesterol) or high triglycerides that reflect atherogenic indices. This research sought to assess the CVD risk of these particular indicators in type 2 diabetes mellitus patients in Osogbo, Osun State, Nigeria. We applied a correlational study to examine the composite of an individual physical, biochemical, and physiological traits. The research involved two groups: experimental group (diabetic) and control group (non-diabetic). Each group consists of one hundred (100) participants, recruited from selected four (4) primary health facilities in Osogbo, Osun State, Nigeria. Fasting veinous blood sample was obtained from respondents, for laboratory assay, using enzyme assay technique. Our findings revealed substantial increased systolic and diastolic hypertension, low density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) levels in experimental group (diabetic) compared to control (non-diabetic). Cholesterol ratios, serum interleukin-6 levels as well as raised troponin I (TnI), were observed in type 2 diabetes mellitus patients. Diabetic patients in Osogbo, Nigeria are at a greater risk of cardiovascular disease (CVD) as indicated by these unhealthy physiological and biochemical conditions. Timely detection and management of diabetes and CVD risk factors are, thus, essential.

Keywords : Interleukin-6 (IL-6), Cardiac Troponin I (TnI), Type 2 Diabetes Mellitus (T2DM), Osun State Nigeria, Atherogenic Index, Cardiovascular Disease (CVD).

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