Authors : Abdulkareem Qasem Moqbel; Lina Jamal Hameed; Emad Shamsan; Ram Prasad Chaulagain; Nand Lal; Radheshyam Gupta; Fikadu Balcha; Hongjuan Cui

Volume/Issue : Volume 8 - 2023, Issue 9 - September

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/yr8xr3th

DOI : https://doi.org/10.5281/zenodo.8413681

Abstract : Background: Obesity, characterized by excessive body fat accumulation, can trigger inflammation and independently disrupt vital organ functions like the liver. This study aims to assess and compare the impact of obesity on serum liver enzyme activity among obese and non-obese Yemeni adult individuals.Methods: A total of 250 healthy Yemeni individuals were divided into two categories: 100 obese (BMI ≥25) and 150 non-obese (BMI <24.9). Data was collected via a standard questionnaire. A semiautomatic instrument was used to measure the activity of serum ALT, AST, and GGT.Results: The results revealed that the average age, weight, height, and BMI of obese groups were substantially higher than those of non-obese groups (P < 0.000). The mean levels of ALT, AST, and GGT were higher in obese groups when compared to non-obese groups (P < 0.000). A significantly positive correlation of BMI with ALT, AST, and GGT in obese groups (r = 0.329, P = 0.001, r = 0.280, P = 0.005, r = 0.213, P = 0.033; respectively). In multiple linear regression analysis, obesity was significantly independently associated with liver enzymes of ALT (B=2.05, P = 0.002), AST (B=0.97, P = 0.050), and GGT (B=1.64, P = 0.003) after adjustment for BMI.Conclusion: Our study found significant increases in liver enzymes (ALT, AST, GGT) among the obese group, with stronger associations as BMI and obesity severity increased. A comprehensive prospective study is required to validate the interaction between obesity and liver enzymes.

Keywords : Liver Enzymes, ALT, AST, GGT, Obesity, BMI