Authors : Harry Andromeda; Zulfikri Mukhtar; Refli Hasan, Harris Hasan, Teuku Bob Haykal, Yuke Sarastri
Volume/Issue : Volume 7 - 2022, Issue 3 - March
Google Scholar : https://bit.ly/3IIfn9N
Scribd : https://bit.ly/3JVQ8Ce
DOI : https://doi.org/10.5281/zenodo.6400163
Acute coronary syndrome is one of many
primary causes of mortality and morbidity in the world.
Interventional therapy has been known to cause
complications, which is in-stent restenosis (ISR). The
CHA2DS2-VASc score consisted of 8 components that
were thought to be associated with ISR. Several studies
have suggested using the CHA2DS2-VASc score to
predict the occurrence of ISR.
Objective: The objective of this study was to determine
whether the incidence of ISR in patients with acute
coronary syndrome undergoing percutaneous coronary
intervention at Haji Adam Malik General Hospital
Medan was correlated with the CHA2DS2-VASc score.
Methods: This was an observational analytic study, with
a retrospective cohort design. The study was carried out
at Haji Adam Malik General Hospital Medan since July
2020. The research sample was ACS patients at Haji
Adam Malik General Hospital Medan. ISR was assessed
by finding ≥50% narrowing of the stent or peri-stent
segments luminal diameter at follow-up coronary
angiography. To assess the relation between the
CHA2DS2-VASc score and the incidence of ISR, bivariate
analysis was performed. A p value < 0.05 was considered
to be significant statistically.
Results: From the total of 96 people, 46 (47.92%) of whom
had ISR. The group that experienced ISR, in general,
consisted of older mean age, more history of congestive
heart failure, stroke, dyslipidemia, hypertension, and
diabetes mellitus, as well as lower LVEF values, higher
median FBG, lower mean HDL, and higher mean LDL.
The variables that had a statistically significant
association with ISR (p < 0.05) were hypertension,
dyslipidemia, congestive heart failure, LVEF, HDL, LDL,
and CHA2DS2-VASc score. Chi-square analysis of the
CHA2DS2-VASc score and the incidence of ISR showed
that the two variables had a significant correlation
statistically (p < 0.0001; RR 14.58; CI = 6,026-44,997).
Conclusion: The CHA2DS2-VASc score was statistically
significant with the incidence of ISR in patients with ACS
undergoing percutaneous coronary intervention at Haji
Adam Malik General Hospital Medan (p < 0.001; RR
14.58; CI = 6,026-44,997). Patient characteristics that
were significant statistically with the occurence of ISR
were hypertension, dyslipidemia, congestive heart failure,
LVEF, HDL, and LDL.
Keywords : CHA2DS2-VASc Score, In-Stent Restenosis, Acute Coronary Syndrome.