Accumulating evidence identifies dietary intake may trigger chronic low-grade inflammation as potential mechanisms contributing to insulin resistance. However, studies regarding dietary inflammatory were inconsistent. An analysis of diet quality using dietary inflammatory index (DII) was conducted to investigate whether individual nutrition intake is proinflammation or antiinflammation. The objective of this study was to understand the association between DII score and TNF-α in the normoweight and obese group. A cross-sectional study comprised 210 Indonesian adults in Jakarta. DII scores derived from two days of food recall were calculated based on 40 nutrients and food components, then serum TNF-α were measured using ELISA. Our data indicate a more proinflammatory diet, reflected by higher DII scores, was slightly higher in the obese group than the normoweight group (p=0,407). The overall DII score was not associated with serum TNF-α after adjustment for covariates (ß=0,001, p=0,895). However, when the DII score was classified into normoweight and obese group, the DII score in the normoweight group was significantly associated with serum TNF-α after adjustment for covariates (ß= 0,013, p=0,036), but not in the obese group. In conclusion, a positive association between DII score and serum TNF-α in the normoweight group level suggests that the diet's inflammatory properties regulate adipose tissue inflammation.

Keywords : Dietary quality, dietary inflammatory score, lowgrade inflammation, obesity, TNF-α