Authors :
A.Benhamdaneb (Dr); A. Halouache*a (Dr); A. , A. Guerbouba (Pr); M.Tamzaout
Volume/Issue :
Volume 6 - 2021, Issue 11 - November
Google Scholar :
http://bitly.ws/gu88
Scribd :
https://bit.ly/3p9WvKa
Abstract :
We report the case of a rare association of
Hashimoto's thyroiditis with Crohn's disease .
17-year-old boy with a 3-year history of fistulizing
Crohn's disease treated with biotherapy , admitted to the
gastroenterology department for an exacerbation of his
disease . He complained of diarrhea, abdominal pain,
bradycardia and asthenia. The biological workup was in
favor of a high CRP and anemia (Hb at 11g/dl). The
etiological workup of the bradycardia showed: a TSH at
8.5IU/ml (0. 4-4.78IU/ml) LT4 at 0.46ng/dl (0.7-1.48ng/dl)
. Antithyroperoxidase antibodies were 567IU/ml and
antityroglobulin antibodies at 150IU/ml (lower than 0.6) .
Cervical ultrasound was in favor of Hashimoto's
thyroiditis. Abdominal imaging revealed active
inflammatory ileocoecal involvement. On the basis of
these data, a diagnosis of autoimmune Hashimoto's
thyroiditis associated with Crohn's disease was made, and
the patient was put on Levothyroxine .
In front of the increasing number of reported cases
of their association; several authors suggested the
existence of a correlation between autoimmune thyroiditis
and IBD, many explanations were presented, among
which the immunological theory described by Roura-Mir
C and his team, whose strong argument is the presence of
an imbalance of type TH2 in the 2 diseases, Now, it
became recognized that the balance Th1/Th2 controls the
immune system. The second is that which suggests that a
common genetic etiology contributes to the coexistence of
these diseases
Keywords :
Hashimoto, Thyroiditis , Crohn's Disease
We report the case of a rare association of
Hashimoto's thyroiditis with Crohn's disease .
17-year-old boy with a 3-year history of fistulizing
Crohn's disease treated with biotherapy , admitted to the
gastroenterology department for an exacerbation of his
disease . He complained of diarrhea, abdominal pain,
bradycardia and asthenia. The biological workup was in
favor of a high CRP and anemia (Hb at 11g/dl). The
etiological workup of the bradycardia showed: a TSH at
8.5IU/ml (0. 4-4.78IU/ml) LT4 at 0.46ng/dl (0.7-1.48ng/dl)
. Antithyroperoxidase antibodies were 567IU/ml and
antityroglobulin antibodies at 150IU/ml (lower than 0.6) .
Cervical ultrasound was in favor of Hashimoto's
thyroiditis. Abdominal imaging revealed active
inflammatory ileocoecal involvement. On the basis of
these data, a diagnosis of autoimmune Hashimoto's
thyroiditis associated with Crohn's disease was made, and
the patient was put on Levothyroxine .
In front of the increasing number of reported cases
of their association; several authors suggested the
existence of a correlation between autoimmune thyroiditis
and IBD, many explanations were presented, among
which the immunological theory described by Roura-Mir
C and his team, whose strong argument is the presence of
an imbalance of type TH2 in the 2 diseases, Now, it
became recognized that the balance Th1/Th2 controls the
immune system. The second is that which suggests that a
common genetic etiology contributes to the coexistence of
these diseases
Keywords :
Hashimoto, Thyroiditis , Crohn's Disease
