Authors :
Abdulkareem Qasem Moqbel; Lina Jamal Hameed; Mustafa A.S. Dehwah; Yi-Hua Sun
Volume/Issue :
Volume 8 - 2023, Issue 11 - November
Google Scholar :
https://tinyurl.com/ypy67jhz
Scribd :
https://tinyurl.com/2vwndu3h
DOI :
https://doi.org/10.5281/zenodo.10203410
Abstract :
Background.
Breast cancer (BC) is one of Yemeni women's
leading causes of cancer mortality. In BC patients,
supraclavicular radiation exposure may result in thyroid
dysfunction, including hypothyroidism (HT). This case-
control study aimed to evaluate the association of BC
with the levels of thyroid hormones and anti-TPO Ab in
Yemeni women and the influence of obesity, menopause,
and treatment as effect modifiers of this association.Methods.
The serum levels of FT3, TSH, FT4, anti-TPO Ab,
CEA, and CA 15-3 were measured in 147 BC females (59
pretreatment and 88 post-treatment) and 70 healthy
controls.Results.
The results showed that BC patients had a
significantly higher level of TSH than healthy controls (P
= 0.048). A considerably higher level of TSH and a lower
level of FT3 in post-treatment compared to pretreatment
BC patients were found and associated with increased
BMI and age (P < 0.05) in postmenopausal patients and
decreased FT4 levels. Positive anti-TPO Ab levels were
significantly higher in the BC group and post-treatment
subgroup compared to the healthy control (22.4% vs.
3.3%; 22.7% vs. 3.3%, P = 0.001, respectively). HT
prevalence was considerably greater in post-treatment
BC patients than pretreatment BC patients (26.1% vs.
10.2%, P = 0.017).Conclusion.
This study found a strong link between breast
cancer, and thyroid function, and autoimmunity in
Yemeni women with breast cancer, especially those who
had recently been treated. A significantly higher
prevalence of HT, a higher level of TSH, and a lower
level of FT3 in post-treatment compared to pretreatment
BC patients were associated with increasing BMI and
age in post-menopausal patients. Further studies with a
large sample size in the future are recommended.
Keywords :
Breast Cancer, Free Triiodothyronine, Free Thyroxin, Thyroid Stimulating Hormone, Anti-Thyroid Peroxidase Antibody.
Background.
Breast cancer (BC) is one of Yemeni women's
leading causes of cancer mortality. In BC patients,
supraclavicular radiation exposure may result in thyroid
dysfunction, including hypothyroidism (HT). This case-
control study aimed to evaluate the association of BC
with the levels of thyroid hormones and anti-TPO Ab in
Yemeni women and the influence of obesity, menopause,
and treatment as effect modifiers of this association.Methods.
The serum levels of FT3, TSH, FT4, anti-TPO Ab,
CEA, and CA 15-3 were measured in 147 BC females (59
pretreatment and 88 post-treatment) and 70 healthy
controls.Results.
The results showed that BC patients had a
significantly higher level of TSH than healthy controls (P
= 0.048). A considerably higher level of TSH and a lower
level of FT3 in post-treatment compared to pretreatment
BC patients were found and associated with increased
BMI and age (P < 0.05) in postmenopausal patients and
decreased FT4 levels. Positive anti-TPO Ab levels were
significantly higher in the BC group and post-treatment
subgroup compared to the healthy control (22.4% vs.
3.3%; 22.7% vs. 3.3%, P = 0.001, respectively). HT
prevalence was considerably greater in post-treatment
BC patients than pretreatment BC patients (26.1% vs.
10.2%, P = 0.017).Conclusion.
This study found a strong link between breast
cancer, and thyroid function, and autoimmunity in
Yemeni women with breast cancer, especially those who
had recently been treated. A significantly higher
prevalence of HT, a higher level of TSH, and a lower
level of FT3 in post-treatment compared to pretreatment
BC patients were associated with increasing BMI and
age in post-menopausal patients. Further studies with a
large sample size in the future are recommended.
Keywords :
Breast Cancer, Free Triiodothyronine, Free Thyroxin, Thyroid Stimulating Hormone, Anti-Thyroid Peroxidase Antibody.
