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Association of Serum Vitamin D Levels with Generalized Musculoskeletal Pain in OPD Patients – A Prospective Study


Authors : Dr. Ayush Patel; Dr. Dhruv Lashkare; Dr. Kunal Shrivastava; Dr. Sachin Samaiya

Volume/Issue : Volume 11 - 2026, Issue 4 - April


Google Scholar : https://tinyurl.com/4m79e2bt

Scribd : https://tinyurl.com/4xytbfmt

DOI : https://doi.org/10.38124/ijisrt/26apr1253

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Background: Generalized musculoskeletal pain is a common complaint among patients attending outpatient departments and is often multifactorial. Vitamin D plays an important role in bone health, muscle function, and pain modulation, and its deficiency has been associated with chronic musculoskeletal pain and functional impairment. Several studies have reported a significant association between low serum vitamin D levels and chronic widespread musculoskeletal pain, and improvement in symptoms has been observed after vitamin D supplementation.  Objectives: To evaluate the association between serum vitamin D levels and generalized musculoskeletal pain in outpatient department patients and to assess the effect of vitamin D correction on pain severity.  Methods: This prospective cohort study included 220 adult patients presenting with generalized musculoskeletal pain for ≥3 months in the orthopaedics outpatient department. Serum 25(OH)D levels were measured and categorized as deficient, insufficient, and sufficient. Pain severity was assessed using the Visual Analog Scale (VAS), and patients were followed for six months. Vitamin D deficient patients received supplementation and were reassessed at follow-up.

Keywords : Vitamin D deficiency, Musculoskeletal Pain, Serum Vitamin D, VAS Score, OPD, Prospective Cohort Study

Background: Generalized musculoskeletal pain is a common complaint among patients attending outpatient departments and is often multifactorial. Vitamin D plays an important role in bone health, muscle function, and pain modulation, and its deficiency has been associated with chronic musculoskeletal pain and functional impairment. Several studies have reported a significant association between low serum vitamin D levels and chronic widespread musculoskeletal pain, and improvement in symptoms has been observed after vitamin D supplementation.  Objectives: To evaluate the association between serum vitamin D levels and generalized musculoskeletal pain in outpatient department patients and to assess the effect of vitamin D correction on pain severity.  Methods: This prospective cohort study included 220 adult patients presenting with generalized musculoskeletal pain for ≥3 months in the orthopaedics outpatient department. Serum 25(OH)D levels were measured and categorized as deficient, insufficient, and sufficient. Pain severity was assessed using the Visual Analog Scale (VAS), and patients were followed for six months. Vitamin D deficient patients received supplementation and were reassessed at follow-up.

Keywords : Vitamin D deficiency, Musculoskeletal Pain, Serum Vitamin D, VAS Score, OPD, Prospective Cohort Study

Paper Submission Last Date
31 - May - 2026

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