Association of Tumor Suppressor Protein (TP53) in the Progression of Breast Cancer


Authors : Drashti Rao; Shreyansh Sharma; Hariom Sharma; Dr. Sumitra Datta; Dr. Jignesh Gondaliya; Sapna Patel

Volume/Issue : Volume 8 - 2023, Issue 1 - January

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3iPCRTu

DOI : https://doi.org/10.5281/zenodo.7549503

The most frequent genetic alteration in human cancer is TP53 mutation. TP53 mutation in breast cancer is linked to more aggressive disease and the worst overall survival rate. Compared to other solid tumours, breast cancer has a lower mutation frequency. Breast cancer treatment may benefit from molecular pathological analysis of the structure and expression of the TP53 pathway's components for diagnosis, prognostic evaluation, and, ultimately treatment. In some studies, the TP53 mutation has been linked to a good prognosis, while in other studies, it has been linked to a poor prognosis. The fact that the studies were conducted on various tumour types and with various therapy regimens may be the cause of these disparate results. The apoptosis, cell cycle arrest, and senescence in response to stress are the main topics of this review of recent developments in TP53 research. We also go over TP53-prevalence, prognosis and detection of the mutation for treating human cancer. Methods: Literature review of English language papers available through PubMed and Google Scholar.

Keywords : TP53, Breast Cancer, Mutation, Mutant P53, Human Cancers.

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