Authors :
Soumya Ranjan Mohanty; Mallavarapu Manisha; Manish Kumar
Volume/Issue :
Volume 10 - 2025, Issue 7 - July
Google Scholar :
https://tinyurl.com/ke752jyj
Scribd :
https://tinyurl.com/2uwad54z
DOI :
https://doi.org/10.38124/ijisrt/25jul1587
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Cushing’s syndrome is a rare disorder with varied clinical manifestations, often leading to delayed diagnosis. We
report a case of a 35-year-old woman presenting with worsening dyspnea, secondary amenorrhea, and proximal muscle
weakness. Initial evaluation revealed congestive heart failure and poorly controlled diabetes. Further endocrinological workup
confirmed ACTH-independent Cushing’s syndrome secondary to an adrenal adenoma. Following surgical adrenalectomy, the
patient showed significant clinical improvement. This case highlights the importance of a high index of suspicion for endocrine
disorders in patients with systemic symptoms like heart failure and myopathy.
Keywords :
Cushing’s Syndrome, ACTH-Independent, Adrenal Adenoma, Proximal Myopathy, Secondary Amenorrhea, Congestive Cardiac Failure.
References :
- Nieman LK, Biller BM, Findling JW, et al. The diagnosis of Cushing's syndrome: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2008;93(5):1526–1540. https://doi.org/10.1210/jc.2008-0125
- Lacroix A, Feelders RA, Stratakis CA, Nieman LK. Cushing's syndrome. Lancet. 2015;386(9996):913–927. https://doi.org/10.1016/S0140-6736(14)61375-1
- Newell-Price J, Bertagna X, Grossman AB, Nieman LK. Cushing’s syndrome. Lancet. 2006;367(9522):1605–1617. https://doi.org/10.1016/S0140-6736(06)68699-6
Cushing’s syndrome is a rare disorder with varied clinical manifestations, often leading to delayed diagnosis. We
report a case of a 35-year-old woman presenting with worsening dyspnea, secondary amenorrhea, and proximal muscle
weakness. Initial evaluation revealed congestive heart failure and poorly controlled diabetes. Further endocrinological workup
confirmed ACTH-independent Cushing’s syndrome secondary to an adrenal adenoma. Following surgical adrenalectomy, the
patient showed significant clinical improvement. This case highlights the importance of a high index of suspicion for endocrine
disorders in patients with systemic symptoms like heart failure and myopathy.
Keywords :
Cushing’s Syndrome, ACTH-Independent, Adrenal Adenoma, Proximal Myopathy, Secondary Amenorrhea, Congestive Cardiac Failure.
