Background: Locally advanced breast cancer encompasses a heterogeneous collection of breast neoplasms, constituting approximately 10 to 20% of newly diagnosed breast cancer cases annually. The patient often presents with an ulcerative lesion in the breast with foul-smelling or bloody discharge associated with supra clavicular lymphadenopathy and axillary lymphadenopathy. Case report: In this study, we reported a case of a 48-year-old female with complaints of an ulcerated lesion with severe pain over the right breast and foul-smelling serosanguinous discharge from the ulcer. Later, it was diagnosed as a case of carcinoma of the right breast stage cT4bN1Mx. The patient was given neoadjuvant chemotherapy and three sessions of hyperthermia per week for 22 sessions. Results: The tumor responded well to neoadjuvant chemotherapy and hyperthermia, converting the inoperable tumor into an operable tumor. Conclusion: Combined neoadjuvant chemotherapy and hyperthermia significantly reduce the size of locally advanced breast cancer by converting it into an operable one, and there was a reduction in pain over the ulcer, improving the patient's quality of life.

Keywords : Breast Cancer, Chemosensitizer, Chemotherapy, Hyperthermia, Neoplasm.