Authors : Yogi Andrew Taruk Padang

Volume/Issue : Volume 10 - 2025, Issue 7 - July

Google Scholar : https://tinyurl.com/3meju6n4

Scribd : https://tinyurl.com/j6m9wvrn

DOI : https://doi.org/10.38124/ijisrt/25jul994

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Note : Google Scholar may take 30 to 40 days to display the article.

Abstract : Aortic dissection is a life-threatening condition often associated with connective tissue disorders, particularly Marfan syndrome, which predisposes individuals to aortic dilation and rupture. The Bentall procedure, which involves the replacement of the ascending aorta and aortic valve, is an essential surgical intervention for patients with aortic dissection and valve disease. This study examines the role of the Bentall procedure in managing Stanford A DeBakey Type II aortic dissection, with a focus on patients with Marfan syndrome. The findings highlight the importance of early diagnosis, effective pharmacological management, and timely surgical intervention to improve patient outcomes. While recent studies show promising results, further research is needed to assess long-term outcomes and refine surgical techniques, including minimally invasive approaches, to reduce complications and enhance recovery.

Keywords : Aortic Dissection; Bentall Procedure; Marfan Syndrome; Aortic Valve Replacement; Surgical Intervention.

References :

1. Biancari, F., Mastroiacovo, G., Rinaldi, M., Ferrante, L., Mäkikallio, T., Juvonen, T., Mariscalco, G., El-Dean, Z., Pettinari, M., Rodriguez Lega, J., Pinto, A. G., Perrotti, A., Onorati, F., Wisniewski, K., Demal, T., Kacer, P., Rocek, J., Di Perna, D., Vendramin, I., … Peterss, S. (2024). The David Versus the Bentall Procedure for Acute Type A Aortic Dissection. Journal of Cardiovascular Development and Disease, 11(11), 370. https://doi.org/10.3390/jcdd11110370
2. Erbel, R., Aboyans, V., Boileau, C., Bossone, E., Bartolomeo, R. Di, Eggebrecht, H., Evangelista, A., Falk, V., Frank, H., Gaemperli, O., Grabenwöger, M., Haverich, A., Iung, B., Manolis, A. J., Meijboom, F., Nienaber, C. A., Roffi, M., Rousseau, H., Sechtem, U., … Vrints, C. (2014). 2014 ESC Guidelines on The Diagnosis and Treatment of Aortic Diseases. European Heart Journal, 35(41), 2873–2926. https://doi.org/10.1093/eurheartj/ehu281
3. Gawinecka, J., Schnrath, F., & von Eckardstein, A. (2017). Acute Aortic Dissection: Pathogenesis, Risk Factors and Diagnosis. Swiss Medical Weekly, 147, w14489. https://doi.org/10.4414/smw.2017.14489
4. Graf, J. A. (2022). Detection of Ectopia Lentis Results in Diagnosis of Marfan Syndrome. CRO (Clinical & Refractive Optometry) Journal, 33(3). https://doi.org/10.57204/001c.38690
5. Grewal, N., & Gittenberger-de Groot, A. C. (2018). Pathogenesis of Aortic Wall Complications in Marfan Syndrome. Cardiovascular Pathology, 33, 62–69. https://doi.org/10.1016/j.carpath.2018.01.005
6. Gudbjartsson, T., Ahlsson, A., Geirsson, A., Gunn, J., Hjortdal, V., Jeppsson, A., Mennander, A., Zindovic, I., & Olsson, C. (2020). Acute type A Aortic Dissection – A Review. Scandinavian Cardiovascular Journal, 54(1), 1–13. https://doi.org/10.1080/14017431.2019.1660401
7. Gupta, S. Das, Hoque, M., Mandol, B. C., Islam, M. A., & Chanda, P. K. (2021). Modified Bentall’s Procedure for Aortic Root Aneurysm: A Case Report. Journal of Chittagong Medical College Teachers’ Association, 32(2), 147–150. https://doi.org/10.3329/jcmcta.v32i2.67620
8. Hiratzka, L. F., Bakris, G. L., Beckman, J. A., Bersin, R. M., Carr, V. F., Casey, D. E., Eagle, K. A., Hermann, L. K., Isselbacher, E. M., Kazerooni, E. A., Kouchoukos, N. T., Lytle, B. W., Milewicz, D. M., Reich, D. L., Sen, S., Shinn, J. A., Svensson, L. G., & Williams, D. M. (2010). 2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease. Circulation, 121(13). https://doi.org/10.1161/CIR.0b013e3181d4739e
9. Isselbacher, E. M., Preventza, O., Hamilton Black III, J., Augoustides, J. G., Beck, A. W., Bolen, M. A., Braverman, A. C., Bray, B. E., Brown-Zimmerman, M. M., Chen, E. P., Collins, T. J., DeAnda, A., Fanola, C. L., Girardi, L. N., Hicks, C. W., Hui, D. S., Jones, W. S., Kalahasti, V., Kim, K. M., … Woo, Y. J. (2022). 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease. Journal of the American College of Cardiology, 80(24), e223–e393. https://doi.org/10.1016/j.jacc.2022.08.004
10. Khachatryan, Z., Leontyev, S., Magomedov, K., Haunschild, J., Holzhey, D. M., Misfeld, M., Etz, C. D., & Borger, M. A. (2021). Management of Aortic Root in Type A Dissection: Bentall Approach. Journal of Cardiac Surgery, 36(5), 1779–1785. https://doi.org/10.1111/jocs.15271
11. Le, Y., Zhang, J., Hong, T., & Yang, J. (2024). Coexistence of Type 2 Diabetes Mellitus, Arginine Vasopressin Deficiency, and Marfan Syndrome: A Case Report. Journal of Diabetes Investigation, 15(7), 964–967. https://doi.org/10.1111/jdi.14169
12. Lin, C.-Y., Tung, T.-H., Wu, M.-Y., Tseng, C.-N., & Tsai, F.-C. (2021). Surgical Outcomes of Debakey Type I and Type II Acute Aortic Dissection: A Propensity Score-Matched Analysis in 599 Patients. Journal of Cardiothoracic Surgery, 16(1), 208. https://doi.org/10.1186/s13019-021-01594-9
13. Loeys, B. L., Dietz, H. C., Braverman, A. C., Callewaert, B. L., De Backer, J., Devereux, R. B., Hilhorst-Hofstee, Y., Jondeau, G., Faivre, L., Milewicz, D. M., Pyeritz, R. E., Sponseller, P. D., Wordsworth, P., & De Paepe, A. M. (2010). The Revised Ghent Nosology for the Marfan Syndrome. Journal of Medical Genetics, 47(7), 476–485. https://doi.org/10.1136/jmg.2009.072785
14. Nardi, P., Bassano, C., Pisano, C., Altieri, C., Ferrante, M., Greci, M., Buioni, D., Bertoldo, F., Farinaccio, A., & Ruvolo, G. (2021). The Effects of Debakey Type Acute Aortic Dissection and Preoperative Peripheral and Cardiac Malperfusion on The Outcomes After Surgical Repair. Polish Journal of Cardio-Thoracic Surgery, 18(1), 1–7. https://doi.org/10.5114/kitp.2021.105187
15. Noori, M. A. M., Shah, K., Fichadiya, H., Adeosun, M., Jesani, S., Edmund Appiah-Kubi, E. A.-K., Saeed, H., Sherif Elkattawy, S. E., & Joshi, M. (2022). Painless Presentation of a Deadly Disease: Type A Aortic Dissection Requiring the Bentall Procedure. European Journal of Case Reports in Internal Medicine, 9(3), 003197. https://doi.org/10.12890/2022_003197
16. Nordon, I. M., Hinchliffe, R. J., Loftus, I. M., Morgan, R. A., & Thompson, M. M. (2011). Management of Acute Aortic Syndrome and Chronic Aortic Dissection. CardioVascular and Interventional Radiology, 34(5), 890–902. https://doi.org/10.1007/s00270-010-0028-3
17. Papachristodoulou, A., Ghibes, P., Pentara, N. V., Alexandratou, M., Levitin, A., Gadani, S., Partovi, S., Psoma, E., Rafailidis, V., & Prassopoulos, P. (2025). CT Angiography of Acute Aortic Syndrome in Patients with Chronic Kidney Disease. The International Journal of Cardiovascular Imaging, 41(4), 681–693. https://doi.org/10.1007/s10554-025-03336-7
18. Shah, V. N., Kilcoyne, M. F., Buckley, M., Sicouri, S., & Plestis, K. A. (2021). The Mini-Bentall Approach: Comparison With Full Sternotomy. JTCVS Techniques, 7, 59–66. https://doi.org/10.1016/j.xjtc.2021.01.025
19. Vignaraja, V., Sharma, S., & Dindyal, S. (2024). Acute Aortic Syndrome. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK576402/
20. Yu, C., & Jeremy, R. W. (2018). Angiotensin, Transforming Growth Factor Β And Aortic Dilatation in Marfan Syndrome: of Mice and Humans. IJC Heart & Vasculature, 18, 71–80. https://doi.org/10.1016/j.ijcha.2018.02.009