Authors : Dr. Anam Saiyed; Jagdish Buch

Volume/Issue : Volume 11 - 2026, Issue 2 - February

Google Scholar : https://tinyurl.com/yuw7nvs4

Scribd : https://tinyurl.com/mr428ftu

DOI : https://doi.org/10.38124/ijisrt/26feb813

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Bone grafting remains fundamental to regenerative therapy in dentistry and orthopaedics, enabling reconstruction of skeletal defects while supporting biological healing. Contemporary advances in tissue processing and sterilization science have transformed human bone allografts into reliable regenerative scaffolds with predictable clinical performance. This review provides a comprehensive discussion of graft classifications, bone bank–based procurement and laboratory processing workflows performed within our facility, scaffold biology, mechanisms of gamma irradiation–induced DNA fragmentation, immunological and racial compatibility, and clinical outcomes. Emphasis is placed on the biological behaviour of processed allografts, their integration dynamics, safety profile, and translational value in modern surgical practice.

Keywords : Bone Allograft, Scaffold Biology, Demineralized Bone Matrix, Gamma Irradiation, Bone Bank Processing, Immunological Compatibility, Tissue Engineering.

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