Authors :
Gongutri Borah; Preetismita Borah
Volume/Issue :
Volume 8 - 2023, Issue 8 - August
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/4cw7xnw3
DOI :
https://doi.org/10.5281/zenodo.8320796
Abstract :
Multicomponent reactions (MCRs) have
emerged as transformative cornerstones in modern drug
development, revolutionizing the synthesis of complex
molecular architectures. Beyond traditional methods,
MCRs offer unparalleled advantages by enabling the
concurrent assembly of multiple reactants into intricate
structures through a single, streamlined process. This
abstract delves into the significance of MCRs in drug
development, highlighting their facile nature and diverse
applications. Traditional drug synthesis methods often
involve a series of stepwise reactions, resulting in
prolonged timelines, lower yields, and increased costs. In
contrast, MCRs expedite synthesis by condensing several
reactions into a single step, thereby accelerating drug
discovery and development. Their inherent atom- and
step-economy fosters efficiency, while the reduced
number of purification steps minimizes resource
consumption. The versatility of MCRs facilitates the
creation of structurally diverse compounds, critical for
exploring new biological targets and pathways. The
broad scope of reactants allows the integration of
various functional groups into a single molecule,
enhancing drug potency, selectivity, and bioavailability.
Furthermore, MCRs enable the incorporation of
privileged scaffolds, expediting the optimization of lead
compounds and the generation of focused compound
libraries. The review also underscores the impact of
MCRs on addressing medicinal chemistry challenges.
Their application in fragment-based drug design and
diversity-oriented synthesis presents innovative
strategies for hit identification and lead optimization.
MCRs have been pivotal in producing bioactive
molecules with intricate 3D architectures, targeting
protein-protein interactions and challenging binding
pockets that were once deemed undruggable. However,
the successful application of MCRs in drug development
demands a profound understanding of reaction
mechanisms, substrate compatibility, and
stereochemistry. Computational tools and predictive
models have aided in rationalizing reaction outcomes,
enabling efficient reaction design and optimization. In
conclusion, multicomponent reactions stand as powerful
tools beyond traditional methods, reshaping the
landscape of drug development. Their facile execution,
synthetic efficiency, and structural diversity capabilities
position them as pivotal techniques in the creation of
innovative therapeutic agents. As research in this field
continues to evolve, the seamless integration of
multicomponent reactions into the drug developmentprocess holds the promise of accelerating the discovery
of novel treatments for a myriad of diseases.
Keywords :
Multicomponent reactions; Drugs; Biological activity; Isocyanide; Anticancer; Anti-inflammatory.
Multicomponent reactions (MCRs) have
emerged as transformative cornerstones in modern drug
development, revolutionizing the synthesis of complex
molecular architectures. Beyond traditional methods,
MCRs offer unparalleled advantages by enabling the
concurrent assembly of multiple reactants into intricate
structures through a single, streamlined process. This
abstract delves into the significance of MCRs in drug
development, highlighting their facile nature and diverse
applications. Traditional drug synthesis methods often
involve a series of stepwise reactions, resulting in
prolonged timelines, lower yields, and increased costs. In
contrast, MCRs expedite synthesis by condensing several
reactions into a single step, thereby accelerating drug
discovery and development. Their inherent atom- and
step-economy fosters efficiency, while the reduced
number of purification steps minimizes resource
consumption. The versatility of MCRs facilitates the
creation of structurally diverse compounds, critical for
exploring new biological targets and pathways. The
broad scope of reactants allows the integration of
various functional groups into a single molecule,
enhancing drug potency, selectivity, and bioavailability.
Furthermore, MCRs enable the incorporation of
privileged scaffolds, expediting the optimization of lead
compounds and the generation of focused compound
libraries. The review also underscores the impact of
MCRs on addressing medicinal chemistry challenges.
Their application in fragment-based drug design and
diversity-oriented synthesis presents innovative
strategies for hit identification and lead optimization.
MCRs have been pivotal in producing bioactive
molecules with intricate 3D architectures, targeting
protein-protein interactions and challenging binding
pockets that were once deemed undruggable. However,
the successful application of MCRs in drug development
demands a profound understanding of reaction
mechanisms, substrate compatibility, and
stereochemistry. Computational tools and predictive
models have aided in rationalizing reaction outcomes,
enabling efficient reaction design and optimization. In
conclusion, multicomponent reactions stand as powerful
tools beyond traditional methods, reshaping the
landscape of drug development. Their facile execution,
synthetic efficiency, and structural diversity capabilities
position them as pivotal techniques in the creation of
innovative therapeutic agents. As research in this field
continues to evolve, the seamless integration of
multicomponent reactions into the drug developmentprocess holds the promise of accelerating the discovery
of novel treatments for a myriad of diseases.
Keywords :
Multicomponent reactions; Drugs; Biological activity; Isocyanide; Anticancer; Anti-inflammatory.
