Beyond Traditional Methods: Facile Multicomponent Reactions as Cornerstones of Drug Development

Authors : Gongutri Borah; Preetismita Borah

Volume/Issue : Volume 8 - 2023, Issue 8 - August

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Multicomponent reactions (MCRs) have emerged as transformative cornerstones in modern drug development, revolutionizing the synthesis of complex molecular architectures. Beyond traditional methods, MCRs offer unparalleled advantages by enabling the concurrent assembly of multiple reactants into intricate structures through a single, streamlined process. This abstract delves into the significance of MCRs in drug development, highlighting their facile nature and diverse applications. Traditional drug synthesis methods often involve a series of stepwise reactions, resulting in prolonged timelines, lower yields, and increased costs. In contrast, MCRs expedite synthesis by condensing several reactions into a single step, thereby accelerating drug discovery and development. Their inherent atom- and step-economy fosters efficiency, while the reduced number of purification steps minimizes resource consumption. The versatility of MCRs facilitates the creation of structurally diverse compounds, critical for exploring new biological targets and pathways. The broad scope of reactants allows the integration of various functional groups into a single molecule, enhancing drug potency, selectivity, and bioavailability. Furthermore, MCRs enable the incorporation of privileged scaffolds, expediting the optimization of lead compounds and the generation of focused compound libraries. The review also underscores the impact of MCRs on addressing medicinal chemistry challenges. Their application in fragment-based drug design and diversity-oriented synthesis presents innovative strategies for hit identification and lead optimization. MCRs have been pivotal in producing bioactive molecules with intricate 3D architectures, targeting protein-protein interactions and challenging binding pockets that were once deemed undruggable. However, the successful application of MCRs in drug development demands a profound understanding of reaction mechanisms, substrate compatibility, and stereochemistry. Computational tools and predictive models have aided in rationalizing reaction outcomes, enabling efficient reaction design and optimization. In conclusion, multicomponent reactions stand as powerful tools beyond traditional methods, reshaping the landscape of drug development. Their facile execution, synthetic efficiency, and structural diversity capabilities position them as pivotal techniques in the creation of innovative therapeutic agents. As research in this field continues to evolve, the seamless integration of multicomponent reactions into the drug developmentprocess holds the promise of accelerating the discovery of novel treatments for a myriad of diseases.

Keywords : Multicomponent reactions; Drugs; Biological activity; Isocyanide; Anticancer; Anti-inflammatory.


Paper Submission Last Date
31 - December - 2023

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