Authors :
Dr. Kavya J Pai; Dr. Pradeepgoud H Patil; Dr. Santosh Patil; Dr. Virupaxi Hattiholi; Dr. Rajendra Mali; Dr. Pradeep Goudar
Volume/Issue :
Volume 10 - 2025, Issue 3 - March
Google Scholar :
https://tinyurl.com/yde4f826
Scribd :
https://tinyurl.com/bdf86a29
DOI :
https://doi.org/10.38124/ijisrt/25mar1441
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Parathyroid adenomas are common causes of primary hyperparathyroidism and present with a wide spectrum of
clinical features, including fatigue, generalized weakness, and depression. We present a case of a 70-year-old female with a
known history of diabetes mellitus and hypertension, who presented with chronic fatigue, generalized weakness, and
depression for two years. Laboratory investigations revealed elevated serum parathyroid hormone (PTH) and calcium
levels. Imaging studies, including a contrast-enhanced CT of the neck, revealed bilateral inferior parathyroid adenomas.
This case highlights the importance of considering parathyroid pathology in patients with unexplained fatigue, weakness,
and mood disturbances. We discuss the diagnostic approach and management, along with a review of the literature on
parathyroid adenomas.
References :
- Lamb, A., McGilvray, R., & Scharfe, A. (2018). Role of CT imaging in the diagnosis of parathyroid adenomas. Journal of Clinical Endocrinology & Metabolism, 103(4), 1463–1470. https://doi.org/10.1210/jc.2017-02298
- Koh, K., Tan, M., & Cheng, C. (2019). Parathyroid adenomas: Clinical presentation, imaging, and surgical outcomes. World Journal of Surgery, 43(6), 1500–1507. https://doi.org/10.1007/s00268-019-04942-x
- Bilezikian, J. P., Silverberg, S. J., & Shane, E. (2018). Primary hyperparathyroidism: Current concepts in diagnosis and management. Journal of Bone and Mineral Research, 33(1), 17-22. https://doi.org/10.1002/jbmr.3334
- Johnson, N. A., Tublin, M. E., & Ogilvie, J. B. (2020). Imaging in primary hyperparathyroidism: A review. World Journal of Radiology, 12(4), 48-66. https://doi.org/10.4329/wjr.v12.i4.48
- Kirkpatrick, C., Sun, Z., & Hamilton, B. (2021). Surgical management of primary hyperparathyroidism: Advances and outcomes. Annals of Surgery, 273(3), 503-512. https://doi.org/10.1097/SLA.0000000000003441
- Randhawa, S., & Mullan, B. P. (2017). Parathyroid adenomas: Imaging techniques and surgical approaches. Endocrine Practice, 23(2), 172-183. https://doi.org/10.4158/EP161687.RA
- Silverberg, S. J., & Bilezikian, J. P. (2019). Clinical presentation of primary hyperparathyroidism in the elderly. Journal of Clinical Endocrinology & Metabolism, 104(7), 3172-3182. https://doi.org/10.1210/jc.2018-02242
Parathyroid adenomas are common causes of primary hyperparathyroidism and present with a wide spectrum of
clinical features, including fatigue, generalized weakness, and depression. We present a case of a 70-year-old female with a
known history of diabetes mellitus and hypertension, who presented with chronic fatigue, generalized weakness, and
depression for two years. Laboratory investigations revealed elevated serum parathyroid hormone (PTH) and calcium
levels. Imaging studies, including a contrast-enhanced CT of the neck, revealed bilateral inferior parathyroid adenomas.
This case highlights the importance of considering parathyroid pathology in patients with unexplained fatigue, weakness,
and mood disturbances. We discuss the diagnostic approach and management, along with a review of the literature on
parathyroid adenomas.