To Formulate and evaluate the bioadhesive
sustain release inserts of prednisolone acetate for
postoperative management and treatment of cataract.
The bioadhesive local delivery system decreases dose
and administration frequency of the drug and helps in
fast healing and patient compliance.
Teflon coated glass moulds were used to formulate
matrix bioadhesive inserts using solvent evaporation
technique and evaluated for invitro drug release
studies. Different formulations of hydroxyl propyl
methyl cellulose (HPMC), sodium carboxy methyl
cellulose (SCMC) in ratios 80:20,70:30,60:40 and 50:50,
along with varying concentration of glycerine as
plasticiser were prepared and evaluated. The Prepared
formulations were evaluated for the parameters such
as weight variation, thickness, folding endurance,
flexibility, stretching strength, drug content, in vitro
drug release, bioadhesion strength, surface pH, swelling
index, % moisture loss, moisture adsorption, sterility
studies and stability studies and optimized.
The formulation ‘PEF-06, 08, 11, & 13’ was
optimised through the Evaluation parameters obtained.
The optimized batches were then studied for invitro,
drug Release, invitro permeation, and sterility and
stability studies. During the studies the duration of
drug release and the retention time of the PEF -06 in
ocular cavity were found excellent.
The formulated bioadhesive insert showed
extended drug release and increased retention time due
to bioadhesive polymers which will help to overcome
the disadvantages of conventional preparations.
Keywords : Ophthalmic Inserts, Eye Inserts, Bioadhesive Inserts, Cataract, Prednisolone.