Bioadhesive Inserts of Prednisolone Acetate for Postoperative Management of Cataract – Development and Evaluation

Authors : Jisha Gopi, Umesh Kumar Sharma

Volume/Issue : Volume 4 - 2019, Issue 8 - August

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 Objective To Formulate and evaluate the bioadhesive sustain release inserts of prednisolone acetate for postoperative management and treatment of cataract. The bioadhesive local delivery system decreases dose and administration frequency of the drug and helps in fast healing and patient compliance.  Methods Teflon coated glass moulds were used to formulate matrix bioadhesive inserts using solvent evaporation technique and evaluated for invitro drug release studies. Different formulations of hydroxyl propyl methyl cellulose (HPMC), sodium carboxy methyl cellulose (SCMC) in ratios 80:20,70:30,60:40 and 50:50, along with varying concentration of glycerine as plasticiser were prepared and evaluated. The Prepared formulations were evaluated for the parameters such as weight variation, thickness, folding endurance, flexibility, stretching strength, drug content, in vitro drug release, bioadhesion strength, surface pH, swelling index, % moisture loss, moisture adsorption, sterility studies and stability studies and optimized.  Results The formulation ‘PEF-06, 08, 11, & 13’ was optimised through the Evaluation parameters obtained. The optimized batches were then studied for invitro, drug Release, invitro permeation, and sterility and stability studies. During the studies the duration of drug release and the retention time of the PEF -06 in ocular cavity were found excellent.  Conclusion The formulated bioadhesive insert showed extended drug release and increased retention time due to bioadhesive polymers which will help to overcome the disadvantages of conventional preparations.

Keywords : Ophthalmic Inserts, Eye Inserts, Bioadhesive Inserts, Cataract, Prednisolone.


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30 - November - 2023

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