Obesity and overweight contribute
significantly to the burden of chronic diseases and
complications globally. The rising prevalence of these
conditions in Nigeria, especially among middle-class
workers has been attributed to the acculturation of
Western dietary patterns, reduced intake of dietary
fibre, and sedentary lifestyles. Considering the risks
associated with obesity and the associated side effects of
orthodox medicine, a lot of studies have been dedicated
to finding alternative treatments with limited side effects
that are affordable hence, the use of medicinal plants
such as Vernonia amygdalina. This study examined the
therapeutic effects of V. amygdalina aqueous leaf extract
on the biomarkers of metabolic syndrome in high-fat
diet (HFD)-induced obese rats. 30 male Wistar rats were
obtained and divided randomly into five groups
containing six rats each. Group A was fed with only
normal rat chow, while a high-fat diet was fed to groups
B, C, D and E with V. amygdalina extract fed to groups
C, D, and E alone after the induction of obesity. The
animals were sacrificed on the 28th day and various
analyses including growth performance, the
concentration of blood glucose, serum lipid profile, and
renal and hepatic function tests were performed. The
group fed with only HFD had significantly high body
weight, blood glucose concentration, serum levels of
cholesterol, triglycerides, and liver and kidney
biomarkers. However, posttreatment of groups C, D, and
E with an aqueous extract of V. amygdalina significantly
reduced these biomarkers to physiological levels and the
organ tissue structure showed improvement. Thus,
indicating the anti-obesity effects and the continuous role
of V. amygdalina in weight loss management and
prevention of obesity.
Keywords :
Obesity, overweight, Vernonia amygdalina, high-fat diet (HFD), cholesterol, triglycerides, liver, kidney, anti-obesity, weight loss