Authors : Atinuke Yusuf; Daniel Ugbomoiko; David Temitope Ogunleye; Olufisayo Famuyiwa; Chika Aladeokin; Elizabeth Abodunrin

Volume/Issue : Volume 11 - 2026, Issue 3 - March

Google Scholar : https://tinyurl.com/8u7ubxwj

Scribd : https://tinyurl.com/k7wavyjn

DOI : https://doi.org/10.38124/ijisrt/26mar526

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Abstract : Background: Dyslipidemia is a central and modifiable cardiovascular risk factor; however, its characterization alongside systemic inflammation, cardiac biomarkers, and renal dysfunction in Nigerian community-dwelling populations remains limited. This study investigated the atherogenic lipid profile and its role within an integrated cardiovascular risk pathway among residents of Ibadan North Local Government, Ibadan, Nigeria.  Methods: A cross-sectional study enrolled 265 participants selected by stratified random sampling from Ibadan North Local Government. Fasting blood samples were analyzed for total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Inflammatory markers (C-reactive protein [CRP] and interleukin-6 [IL-6]), cardiac biomarkers (Troponin I and CK-MB), and renal function parameters (creatinine and urea) were also assessed. Sociodemographic and lifestyle data were obtained via structured questionnaires. Multiple linear regression and descriptive statistics were applied; significance was set at p < 0.05.  Results: The mean TC was 206.16 ± 44.57 mg/dL (borderline high), mean LDL-C was 128.05 ± 39.54 mg/dL (borderline high), mean TG was 109.22 ± 37.17 mg/dL (normal), and mean HDL-C was 54.37 ± 11.27 mg/dL. Alcohol consumption significantly increased dyslipidemia risk (β = 0.221, p < 0.05), while regular exercise was protective (β = −0.379, p < 0.05). In the integrated regression model, dyslipidemia was the strongest independent predictor of cardiovascular risk (β = −0.417, t = −7.407, p < 0.05), followed by elevated Troponin I (β = 0.466, p < 0.05). The full model including demographic and biochemical predictors explained 37.6% of variance in cardiovascular risk (R² = 0.376), with gender (male sex) and systemic inflammation also achieving significance.  Conclusion: Dyslipidemia, particularly borderline-high LDL-C and TC, is prevalent and constitutes the dominant biochemical driver of cardiovascular risk in this population. Its synergism with systemic inflammation and subclinical cardiac injury highlights the need for integrated lipid-inflammatory screening programs and targeted lifestyle interventions in Ibadan North.

Keywords : Dyslipidemia; Lipid Profile; Cardiovascular Risk; C-Reactive Protein; Interleukin-6; Troponin I; Nigeria.

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