Can Organ Failure and Infected Pancreatic Necrosis be Used to Forecast Mortality in Patients with Gallstone-Induced Pancreatitis?


Authors : Dr. Sheyon Yohannan; Dr. Dhruv Kumar Sharma

Volume/Issue : Volume 8 - 2023, Issue 2 - February

Google Scholar : https://bit.ly/3IIfn9N

Scribd : https://bit.ly/3IUGjq5

DOI : https://doi.org/10.5281/zenodo.7677954

Early identification of high-risk patientsin a common emergency like acute gallstone-induced pancreatitis can be difficult. In patients with acute gallstone-induced pancreatitis, persistent organ failure is considered to be the most important cause of mortality. This study strives to understand the relationship between persistent organ failure with infected pancreatic necrosis and its relationship with mortality.  Design We performed a prospective observational study of 219 patients diagnosed with acute gallstone-induced pancreatitis who were admitted to the Department of General Surgery, IGMC, Shimla. We tried to understand the relationship between the type of organ failure (single or multiorgan and systemic), infected pancreatic necrosis, and mortality.  Results In total, 30 of 219 (13.69%) patients with acute GSP developed Persistent Organ Failure (of any type or combination) of whom 15 (6.8%) patients developed an infection of pancreatic necrosis. Mortality was seen in patients who had a concomitant infection of pancreatic necrosis and persistent organ failure (36.36% vs 0%, p=0.04).  Conclusion In patients with infection of pancreatic necrosis, persistent organ failure is associated with increased mortality when compared to patients with absent persistent organ failure. As mortality was absent in patients without infected pancreatic necrosis, the impact on mortality is debatable.

Keywords : Infected Pancreatic Necrosis, Persistent Organ Failure, Acute Gall Stone Induced Pancreatitis, Mortality.

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