Case Report : Undifferentiated Synovial Sarcoma Presenting as a Large Thoracic Mass: A Rare and Challenging Diagnosis


Authors : Dr. Arushi Goyal; Dr. Sanchit Bhandari; Dr. Vivek Gautam

Volume/Issue : Volume 9 - 2024, Issue 10 - October


Google Scholar : https://tinyurl.com/2r5fkh2m

Scribd : https://tinyurl.com/2uz9rzsw

DOI : https://doi.org/10.38124/ijisrt/IJISRT24OCT039

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.


Abstract : Background: Undifferentiated synovial sarcoma (USS) is a rare and aggressive subtype of soft tissue sarcoma. Its presentation as a large thoracic mass poses significant diagnostic and therapeutic challenges.  Case Presentation: A 34-year-old male presented with a three-month history of progressive chest pain and hemoptysis. Imaging studies revealed a large, cystic thoracic mass with pleural effusion. Initial serological testing suggested hydatid cyst, but subsequent testing revealed negative Echinococcus (Hydatid) IgG antibodies.  Diagnostic and Therapeutic Interventions: Repeat fine-needle aspiration cytology (FNAC) was deferred due to revised ultrasound findings indicating a solid fibrocystic vascular lesion. Bronchial artery embolization (BAE) was performed to control life- threatening hemorrhage. Thoracotomy and en-bloc mass excision were subsequently undertaken.  Histopathological Diagnosis: Histopathological examination of the resected specimen revealed undifferentiated synovial sarcoma and spindle cell sarcoma.  Clinical Implications: This case highlights the importance of correlating imaging and serological findings, managing vascular complications, and the efficacy of BAE in controlling hemorrhage. The significance of thoracotomy and mass excision in achieving diagnostic clarity and therapeutic success is underscored.  Conclusion: Undifferentiated synovial sarcoma presenting as a large thoracic mass poses significant diagnostic and therapeutic challenges. A multidisciplinary approach, incorporating imaging, serological testing, and surgical intervention, is crucial for achieving optimal patient outcomes.

Keywords : Undifferentiated Synovial Sarcoma, Thoracic Mass, Bronchial Artery Embolization, Thoracotomy, Soft Tissue Sarcoma.

References :

  1. American Cancer Society. (2022). Soft Tissue Sarcoma.
  2. Singer et al. (2017). Undifferentiated synovial sarcoma: A clinicopathological study. Journal of Surgical Oncology, 115(5), 537-545.
  3. Demicco et al. (2017). Undifferentiated synovial sarcoma: A review. Journal of Clinical Pathology, 70(9), 761-766.
  4. Murphey et al. (2018). Imaging of synovial sarcoma. Radiographics, 38(4), 931-946.
  5. Ladanyi et al. (2002). The der(18)t(X;18) SYT-SSX fusion transcript is a reliable diagnostic marker for synovial sarcoma. Journal of Molecular Diagnostics, 4(2), 59-64.
  6. Italiano et al. (2019). Management of synovial sarcoma. Journal of Surgical Oncology, 119(3), 257-265.
  7. Tanigawa et al. (2018). Bronchial artery embolization for life-threatening hemorrhage. Journal of Vascular and Interventional Radiology, 29(10), 1331-1336.
  8. Billingsley et al. (2018). Soft tissue sarcoma: An update. Journal of Clinical Oncology, 36(2), 164-172.

Background: Undifferentiated synovial sarcoma (USS) is a rare and aggressive subtype of soft tissue sarcoma. Its presentation as a large thoracic mass poses significant diagnostic and therapeutic challenges.  Case Presentation: A 34-year-old male presented with a three-month history of progressive chest pain and hemoptysis. Imaging studies revealed a large, cystic thoracic mass with pleural effusion. Initial serological testing suggested hydatid cyst, but subsequent testing revealed negative Echinococcus (Hydatid) IgG antibodies.  Diagnostic and Therapeutic Interventions: Repeat fine-needle aspiration cytology (FNAC) was deferred due to revised ultrasound findings indicating a solid fibrocystic vascular lesion. Bronchial artery embolization (BAE) was performed to control life- threatening hemorrhage. Thoracotomy and en-bloc mass excision were subsequently undertaken.  Histopathological Diagnosis: Histopathological examination of the resected specimen revealed undifferentiated synovial sarcoma and spindle cell sarcoma.  Clinical Implications: This case highlights the importance of correlating imaging and serological findings, managing vascular complications, and the efficacy of BAE in controlling hemorrhage. The significance of thoracotomy and mass excision in achieving diagnostic clarity and therapeutic success is underscored.  Conclusion: Undifferentiated synovial sarcoma presenting as a large thoracic mass poses significant diagnostic and therapeutic challenges. A multidisciplinary approach, incorporating imaging, serological testing, and surgical intervention, is crucial for achieving optimal patient outcomes.

Keywords : Undifferentiated Synovial Sarcoma, Thoracic Mass, Bronchial Artery Embolization, Thoracotomy, Soft Tissue Sarcoma.

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