Authors :
Dr. Arushi Goyal; Dr. Sanchit Bhandari; Dr. Vivek Gautam
Volume/Issue :
Volume 9 - 2024, Issue 10 - October
Google Scholar :
https://tinyurl.com/2r5fkh2m
Scribd :
https://tinyurl.com/2uz9rzsw
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24OCT039
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Background:
Undifferentiated synovial sarcoma (USS) is a rare
and aggressive subtype of soft tissue sarcoma. Its
presentation as a large thoracic mass poses significant
diagnostic and therapeutic challenges.
Case Presentation:
A 34-year-old male presented with a three-month
history of progressive chest pain and hemoptysis. Imaging
studies revealed a large, cystic thoracic mass with pleural
effusion. Initial serological testing suggested hydatid cyst,
but subsequent testing revealed negative Echinococcus
(Hydatid) IgG antibodies.
Diagnostic and Therapeutic Interventions:
Repeat fine-needle aspiration cytology (FNAC) was
deferred due to revised ultrasound findings indicating a
solid fibrocystic vascular lesion. Bronchial artery
embolization (BAE) was performed to control life-
threatening hemorrhage. Thoracotomy and en-bloc mass
excision were subsequently undertaken.
Histopathological Diagnosis:
Histopathological examination of the resected
specimen revealed undifferentiated synovial sarcoma and
spindle cell sarcoma.
Clinical Implications:
This case highlights the importance of correlating
imaging and serological findings, managing vascular
complications, and the efficacy of BAE in controlling
hemorrhage. The significance of thoracotomy and mass
excision in achieving diagnostic clarity and therapeutic
success is underscored.
Conclusion:
Undifferentiated synovial sarcoma presenting as a
large thoracic mass poses significant diagnostic and
therapeutic challenges. A multidisciplinary approach,
incorporating imaging, serological testing, and surgical
intervention, is crucial for achieving optimal patient
outcomes.
Keywords :
Undifferentiated Synovial Sarcoma, Thoracic Mass, Bronchial Artery Embolization, Thoracotomy, Soft Tissue Sarcoma.
References :
- American Cancer Society. (2022). Soft Tissue Sarcoma.
- Singer et al. (2017). Undifferentiated synovial sarcoma: A clinicopathological study. Journal of Surgical Oncology, 115(5), 537-545.
- Demicco et al. (2017). Undifferentiated synovial sarcoma: A review. Journal of Clinical Pathology, 70(9), 761-766.
- Murphey et al. (2018). Imaging of synovial sarcoma. Radiographics, 38(4), 931-946.
- Ladanyi et al. (2002). The der(18)t(X;18) SYT-SSX fusion transcript is a reliable diagnostic marker for synovial sarcoma. Journal of Molecular Diagnostics, 4(2), 59-64.
- Italiano et al. (2019). Management of synovial sarcoma. Journal of Surgical Oncology, 119(3), 257-265.
- Tanigawa et al. (2018). Bronchial artery embolization for life-threatening hemorrhage. Journal of Vascular and Interventional Radiology, 29(10), 1331-1336.
- Billingsley et al. (2018). Soft tissue sarcoma: An update. Journal of Clinical Oncology, 36(2), 164-172.
Background:
Undifferentiated synovial sarcoma (USS) is a rare
and aggressive subtype of soft tissue sarcoma. Its
presentation as a large thoracic mass poses significant
diagnostic and therapeutic challenges.
Case Presentation:
A 34-year-old male presented with a three-month
history of progressive chest pain and hemoptysis. Imaging
studies revealed a large, cystic thoracic mass with pleural
effusion. Initial serological testing suggested hydatid cyst,
but subsequent testing revealed negative Echinococcus
(Hydatid) IgG antibodies.
Diagnostic and Therapeutic Interventions:
Repeat fine-needle aspiration cytology (FNAC) was
deferred due to revised ultrasound findings indicating a
solid fibrocystic vascular lesion. Bronchial artery
embolization (BAE) was performed to control life-
threatening hemorrhage. Thoracotomy and en-bloc mass
excision were subsequently undertaken.
Histopathological Diagnosis:
Histopathological examination of the resected
specimen revealed undifferentiated synovial sarcoma and
spindle cell sarcoma.
Clinical Implications:
This case highlights the importance of correlating
imaging and serological findings, managing vascular
complications, and the efficacy of BAE in controlling
hemorrhage. The significance of thoracotomy and mass
excision in achieving diagnostic clarity and therapeutic
success is underscored.
Conclusion:
Undifferentiated synovial sarcoma presenting as a
large thoracic mass poses significant diagnostic and
therapeutic challenges. A multidisciplinary approach,
incorporating imaging, serological testing, and surgical
intervention, is crucial for achieving optimal patient
outcomes.
Keywords :
Undifferentiated Synovial Sarcoma, Thoracic Mass, Bronchial Artery Embolization, Thoracotomy, Soft Tissue Sarcoma.