Case Study of Atenolol


Authors : Vikash Kumar Patel; Devashish Jena; Sandip Kumar

Volume/Issue : Volume 10 - 2025, Issue 4 - April


Google Scholar : https://tinyurl.com/kuzk9rwc

Scribd : https://tinyurl.com/5n6p8jv9

DOI : https://doi.org/10.38124/ijisrt/25apr1162

Google Scholar

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Note : Google Scholar may take 15 to 20 days to display the article.


Abstract : Atenolol, which is a cardioselective blocker of the beta-1 adrenergic receptors, is frequently used to treat hypertension, angina pectoris, and cardiac arrhythmias. The following is a case report of a 52-year-old man patient diagnosed with stage 2 hypertension (BP 168/102 mmHg) with a background history of exertional mild angina. Upon baseline assessment, the patient was started on Atenolol 50 mg daily. At 12-week follow-up, the patient demonstrated significant improvement in the control of blood pressure (mean BP lowered to 130/84 mmHg), reduction in the number of anginal attacks, and absence of serious side effects. Heart rate decreased from 88 bpm to 68 bpm with increased exercise tolerance. Slight fatigue was noticed in the initial period but subsided by the fourth week. The case highlights the ability of Atenolol to control both hypertension and accompanying angina, with an excellent safety profile in an outpatient environment. It is also underlines the need for individualized treatment, follow-up, and patient education on compliance and lifestyle change.

Keywords : Atenolol, Hypertension, Beta-Blocker, Angina, Case Study, Cardioselective, Blood Pressure, Heart Rate.

References :

  1. Aberg, H.: Plasma renin activity after the use of a new beta-adrenergic blocking agent (I.C.I. 66,082). International Journal of Clinical Pharmacology 9: 98 (1974a). CAS Google Scholar 
  2. Aberg, H.: Beta-receptors and renin release. New England Journal of Medicine 290: 1026 (1974b). PubMed CAS Google Scholar 
  3. Amende, I.; Simon, R. and Lichtlen, P.R.: Effects of beta-blockade and nitroglycerin on diastolic pressure — volume relation in patients with coronary artery disease. Circulation 54 (Suppl. 2): II–66 (1976). Google Scholar 
  4. Amery, A.; Billiet, L. and Fagard, R.: Beta receptors and renin release. New England Journal of Medicine 290: 284 (1974). PubMed CAS Google Scholar 
  5. Amery, A.; Billiet, L.; Boel, A; Fagard, R.; Reybrouck, T. and Willems, J.: Mechanism of hypotensive effect during beta-adrenergic blockage in hypertensive patients. Haemodynamic and renin response to a new cardioselective agent; Tenormin or I.C.I. 66,082. American Heart Journal 91: 634 (1976). Article PubMed CAS Google Scholar 
  6. Amery, A.; liet, L.; Joosens, J.V.; Meekers, J.; Reybrouck, T. and Van Mieghem, W.: Preliminary report on the haemodynamic response of hypertensive patients treated with a beta-blocker (I.C.I. 66,082). Acta Clinica Belgica 28: 359 (1973). Google Scholar 
  7. Amery, A.; De Plaen, J.-F.; Lijnew, P.; McAinsh, J. and Reybrouck, T.: Relationship between blood level of atenolol and pharmacologic effect. Clinical Pharmacology and Therapeutics 21: 691 (1977). PubMed CAS Google Scholar 
  8. Amery, A.; Lijnen, P.; Fagard, R. and Reybrouck, T.: Inactive renin in human plasma. Lancet 2: 849 (1976a). Google Scholar 
  9. Amery, A.; Lijnen, P.; Fagard, R. and Reybrouck, T.: Plasma renin activity vs. concentration. New England Journal of Medicine 295: 1198 (1976b). Article PubMed CAS Google Scholar 
  10. Amery, A.; Fagard, R.; De Plaen, J.-F.; Lijnen, P. and Reybrouck, T.: The relationship between beta-blockade, hyporeninaemic and hypotensive effect of two beta-blocking agents. Postgraduate Medical Journal 52 (Suppl. 4): 102 (1976c). Article PubMed CAS Google Scholar 
  11. Asbury, M.J.: Retroperitoneal fibrosis after treatment with atenolol. British Medical Journal 1: 492 (1979) Article PubMed CAS Google Scholar 
  12. Astrom, H.: Comparison of the effects on airway conductance of a new selective beta-adrenergic blocking drug, atenolol, and propranolol in asthmatic subjects. Scandinavian Journal of Respiratory Disease 56: 292 (1975). CAS Google Scholar 
  13. Astrom, H. and Jonsson, B.: Haemodynamic effects of different beta-blockers in angina pectoris. Scottish Medical Journal 22: 64 (1977). PubMed CAS Google Scholar 
  14. Astrom, H. and Vallin, H.: Effect of a new beta-adrenergic blocking agent, I.C.I. 66,082, on exercise haemodynamics and airway resistance in angina pectoris. British Heart Journal 36: 1194 (1974). Article PubMed CAS Google Scholar 
  15. Astrom, H. and Vallin, H.: Effect of atenolol on exercise haemodynamics in angina pectoris and hypertension. Postgraduate Medical Journal 53 (Suppl. 3): 84 (1977). PubMed Google Scholar 
  16. Balansard, P.; Chabrillat, Y.; Paulin, R.; Libes, M. and Gerard, R.: Effect of atenolol, a new cardioselective beta-blocker, on plasma renin activity in treatment of hypertension. Acta Cardiologica 32: 229 (1977). PubMed CAS Google Scholar 
  17. Barber, H.E.; Hawksworth, G.M.; Kitteringham, N.R.; Petersen, J.; Petrie, J.C. and Swann, J.M.: Protein binding of atenolol and propranolol to human serum albumin and in human plasma. British Journal of Clinical Pharmacology 6: 446P (1978). Article Google Scholar 
  18. Barrett, A.M.: The pharmacology of atenolol. Postgraduate Medical Journal 53 (Suppl. 3): 58 (1977). PubMed CAS Google Scholar 
  19. Basker, M.A.: Comparison of atenolol (Tenormin) and methyldopa (a multicentre study in general practice). Proceedings of the Royal Society of Medicine 70 (Suppl.5): 19 (1977). PubMed CAS Google Scholar 
  20. Basker, M.A.; Tweed, J.A. and Barker, N.P.: A double-blind comparison of atenolol (’Tenormin’) and methyldopa in the treatment of moderate hypertension in general practice: a multicentre study. Current Medical Research and Opinion 4: 618 (1977). Article PubMed CAS Google Scholar 
  21. Bateman, D.N.; Dean, C.R.; Mucklow, J.C.; Bulpitt, C.J. and Dollery, C.T.: Atenolol and chlorthalidone in combination for hypertension. Unpublished data on file ICI Ltd (1979).
  22. Bayliss, P.F.C. and Duncan, S.M.: The effects of atenolol (Tenormin) and methyldopa on simple tests of central nervous function. British Journal of Clinical Pharmacology 2: 527 (1975). Article PubMed CAS Google Scholar 
  23. Beil, M. and Ulmer, W.T.: Wirkung eines neuen kardioselektiven Betablockers (atenolol) auf den Stromungswiderstand bei chronisch obstruktiven Atemwegserkrankungen. Arzneimittel Forschung 27: 419 (1977). PubMed CAS Google Scholar 
  24. Beilin, L.J.; McGrath, B.; Schofield, T.; Cooper, R. and Benedict, C.: Clinical and pharmacological effects of atenolol (Tenormin). VIII World Congress of Cardiology, p.360, abstract 1076, Tokyo, September 17–23 (1978).
  25. Benson, M.K.: Cardioselectivity studies. Proceedings of the Royal Society of Medicine 70 (Suppl. 5): 48 (1977). PubMed CAS Google Scholar 
  26. Benson, MX; Berrili, W.T.; Sterling, G.M.; Decalmer, P.B.; Chatterjee, S.S.; Croxson, R.S. and Cruickshank, J.M.: Cardioselective and non-cardioselective beta-blockers in reversible obstructive airways disease. Postgraduate Medical Journal 53 (Suppl. 3): 143 (1977). PubMed Google Scholar 
  27. Benson, M.K.; Benill, W.T.; Cruickshank, J.M. and Sterling, G.S.: A comparison of four β-adrenoceptor antagonists in patients with asthma. British Journal of Clinical Pharmacology 5: 415 (1978). Article PubMed CAS Google Scholar 
  28. Berdeaux, A.; Boissier, J.R. and Giudicelli, J.F.: Effects of atenolol on regional myocardial blood flow and ST segment elevation in the canine myocardium. British Journal of Pharmacology 60: 433 (1977). Article CAS Google Scholar 
  29. Berglund, G.; Sannerstedt, R.; Anderson, O.; Wedel, H.; Wilhelmsen, L.; Hansson, L.; Sivertsson, R. and Wikstrand, J.: Coronary heart-disease after treatment of hypertension. Lancet 1: 1 (1978). Article PubMed CAS Google Scholar 
  30. Betts, T.A. and Blake, A.: The psychotropic effects of atenolol in normal subjects. Preliminary findings. Postgraduate Medical Journal 53 (Suppl. 3): 151 (1977). PubMed CAS Google Scholar 
  31. Blackwell, B.: Drug therapy. Patient compliance. New England Journal of Medicine 289: 249 (1973). Article PubMed CAS Google Scholar 
  32. Boye, N.P. and Vale, J.R.: Effect in bronchial asthma of a new beta-adrenergic blocking drug atenolol (ICI 66,082). European Journal of Clinical Pharmacology 11: 11 (1977). Article PubMed CAS Google Scholar 
  33. Braendli, B.; Bucher, H.J.; Nager, F. and Truniger, B.: Atenolol and Bendrofluazid in der Behandlung der mittelschweren und schweren Hypertonie. Schweizerische medizinische Wochenshrift 108: 1976 (1978). CAS Google Scholar 
  34. Brogden, R.N.; Heel, R.C.; Speight, T.M. and Avery, G.S.: Metoprolol: A review of its pharmacological properties and therapeutic efficacy in hypertension and angina pectoris. Drugs 14: 321 (1977). Article PubMed CAS Google Scholar 
  35. Brown, H.C.; Carruthers, S.G.; Johnston, G.D.; Kelly, J.G.; McAinsh, J.; McDevitt, D.G. and Shanks, R.G.: Clinical pharmacologic observations on atenolol, a beta-adrenoceptor blocker. Clinical Pharmacology and Therapeutics 20: 524 (1976). PubMed CAS Google Scholar 
  36. Buhler, F.R.; Burkart, F.; Lutold, B.E.; Kung, M.; Marbet, G. and Pfisterer, M.: Antihypertensive beta blocking action as related to renin and age: A pharmacologic tool to identify pathogenetic mechanisms in essential hypertension. American Journal of Cardiology 36: 653 (1975). Article PubMed CAS Google Scholar 
  37. Buhler, F.R.; Marbet, G.; Patel, U.; and Burkart, F.: Renin-suppressive potency of various beta-adrenergic blocking agents at supine rest and during upright exercise. Clinical Science and Molecular Medicine 48: 61 (1975). Google Scholar 
  38. Carlsen, J.E.; Svendsen, T.L., Christensen, N.J. and Trap-Jensen, J.: The hemodynamic significance of beta-1 selective adrenoceptor-blockade in cigarette smokers. Abstract 15, Clinical Physiology, Lakaresallskapets Riksstamma, Nov. 29–Dec. 2 (1978).
  39. Carlson, C. and Jarvinen, K.A.: Comparison of the effect of the β1-blocking drugs atenolol and metoprolol on bronchial asthma. Allergy 33: 147 (1978). Article PubMed CAS Google Scholar 
  40. Castenfors, J. and Danielsson, M.: Metoprolol and hydrochlorothiazide in a fixed combination once daily in the treatment of hypertension. Current Therapeutic Research 25: 228 (1979).

Atenolol, which is a cardioselective blocker of the beta-1 adrenergic receptors, is frequently used to treat hypertension, angina pectoris, and cardiac arrhythmias. The following is a case report of a 52-year-old man patient diagnosed with stage 2 hypertension (BP 168/102 mmHg) with a background history of exertional mild angina. Upon baseline assessment, the patient was started on Atenolol 50 mg daily. At 12-week follow-up, the patient demonstrated significant improvement in the control of blood pressure (mean BP lowered to 130/84 mmHg), reduction in the number of anginal attacks, and absence of serious side effects. Heart rate decreased from 88 bpm to 68 bpm with increased exercise tolerance. Slight fatigue was noticed in the initial period but subsided by the fourth week. The case highlights the ability of Atenolol to control both hypertension and accompanying angina, with an excellent safety profile in an outpatient environment. It is also underlines the need for individualized treatment, follow-up, and patient education on compliance and lifestyle change.

Keywords : Atenolol, Hypertension, Beta-Blocker, Angina, Case Study, Cardioselective, Blood Pressure, Heart Rate.

Never miss an update from Papermashup

Get notified about the latest tutorials and downloads.

Subscribe by Email

Get alerts directly into your inbox after each post and stay updated.
Subscribe
OR

Subscribe by RSS

Add our RSS to your feedreader to get regular updates from us.
Subscribe