Inlay/onlay restorations have emerged as a conservative and effective approach to restore posterior teeth with extensive cavities, while considering aesthetic, biological, and mechanical factors. This restorative technique has gained significant popularity in routine dental practice and has been extensively documented in scientific literature, owing to advancements in digital technologies and contemporary aesthetic materials. Nonetheless, the effectiveness and durability of inlay/onlay restorations hinge upon achieving optimal alignment between clinical indications, preparation principles, material selection, and bonding protocols. In this article, an updated perspective on this type of partial prosthesis is presented through two clinical cases report: the first case report which describes the rehabilitation of a severely damaged maxillary molar using an Indirect CAD/CAM fabricated ceramic inlay-onlay, thereby shedding light on the latest advancements in this field. The second case report that illustrates the restoration of two pulpless premolars previously filled with GIC (Glass Inomer cement) with two indirect CAD/CAM inlays and onlays using lithium disilicate-reinforced glass-ceramic materials