Authors :
Dr. Vignesh Devaraju
Volume/Issue :
Volume 11 - 2026, Issue 6 - June
Google Scholar :
https://tinyurl.com/ycyz2v9j
Scribd :
https://tinyurl.com/mavwz5vx
DOI :
https://doi.org/10.38124/ijisrt/26jun369
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
Chewing gum has evolved from a recreational confectionery product into a potential adjunct for maintaining oral
health. In recent decades, considerable attention has been directed toward sugar-free chewing gums containing sweeteners
such as xylitol and sorbitol because of their ability to stimulate salivary flow and influence the oral microbial environment.
Increased saliva production contributes to improved buffering capacity, clearance of food debris and enhanced
remineralization of enamel. Novel formulations containing casein phosphopeptide–amorphous calcium phosphate (CPP–
ACP) have further expanded the preventive potential of chewing gum by providing bioavailable calcium and phosphate ions
that support enamel repair. In addition, medicated and nicotine-containing chewing gums have been developed as
alternative delivery systems for therapeutic agents. Evidence from laboratory, clinical and community-based studies
suggests that appropriately formulated chewing gums may contribute to caries prevention, reduction of cariogenic bacteria
and maintenance of oral health when used alongside conventional preventive measures. This review summarizes the
composition, mechanisms of action, therapeutic applications, and oral health benefits of various chewing gum formulations
currently available.
Keywords :
Chewing Gum, Oral Health, Xylitol, Sorbitol, CPP–ACP, Remineralization, Medicated Chewing Gum.
References :
- Mohita marwaha, Manohar bhat. Evaluation of the antimicrobial effectiveness and the effect of dosage and frequency of sugar-free chewing gums on streptococcus mutans count: An in vivo microbiological study. International Journal of Clinical Pediatric Dentistry, January-April 2011;4(1):29-34.
- T.Imfeld. Chewing gums- Facts and Fiction: A review of gum-chewing and oral health. Critical Reviews in Oral Biology &Medicine, 1999;10(3):405-419.
- Brain A. Burt. The use of Sorbitol-and Xylitol-sweetened chewing gum in caries control. Journal of American Dental Association, February 2006;vol 137:190-196.
- Nayak PA, Nayak UA, Khandelwal V. The effect of xylitol on dental caries and oral flora. Clin Cosmet Investig Dent, 2014, November, 10;6,89-94.
- Vashisht R, Indira R, Ramachandran S, Kumar A, Srinivasan MR. Role of casein phosphopeptide amorphous calcium phosphate in remineralization of white spot lesions and inhibition of Streptococcus mutans? J Conserv Dent. 2013 Jul; 16(4):342-346.
- Carmen Llena, Leopoldo Forner, Pilar Baca. Anticariogenicity of Casein Phosphopeptide-Amorphous Calcium Phosphate: A review of literature. The Journal of Contemporary Dental Practice, May 1 2009;10(3)1-9.
- Kinjal R. shah, Tejal A. mehta. Medicated Chewing gum- A mobile oral drug delivery system. Int.J.Pharm Tech Res. 2014,6(1),35-48.
- M A Russell, M Raw, M J Jarvis. Clinical use of nicotine chewing gum. British Medical Journal, 28 june 1980;280(6231):1599-1602.
- Santhosh BP, Jethmalani P, Shashibhushan kk, Subba reddy vv. Effect of casein phosphopeptide - amorphous calcium phosphate containing chewing gum on salivary concentration of calcium and phosphorus: An in-vivo study. Journal of Indian Society of Pedodontics and Preventive Dentistry. 2012 Apr-jun; 30(2):146-150.
- Bar-Hillel R, Feuerstein O, Tickotsky N, Shapira J, Moskovitz M. Effects of amorphous calcium phosphate stabilized by casein phosphopeptides on enamel de- and remineralization in primary teeth: an in vitro study. J Dent Child (Chic). 2012 Jan-Apr;79(1):9-14.
- E.C. Reynolds, F. Cai, N.J. Cochrane, P. Shen, G.D. Walker, M.V. Morgan, C. Reynolds. Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate. J Dent Res,2008, 87(4):344-348.
- Kumar S, Sogi SH, Indushekar KR. Comparative evaluation of the effects of xylitol and sugar-free chewing gums on salivary and dental plaque pH in children. J Indian Soc Pedod Prev Dent. 2013 Oct-Dec;31(4):240-244.
Chewing gum has evolved from a recreational confectionery product into a potential adjunct for maintaining oral
health. In recent decades, considerable attention has been directed toward sugar-free chewing gums containing sweeteners
such as xylitol and sorbitol because of their ability to stimulate salivary flow and influence the oral microbial environment.
Increased saliva production contributes to improved buffering capacity, clearance of food debris and enhanced
remineralization of enamel. Novel formulations containing casein phosphopeptide–amorphous calcium phosphate (CPP–
ACP) have further expanded the preventive potential of chewing gum by providing bioavailable calcium and phosphate ions
that support enamel repair. In addition, medicated and nicotine-containing chewing gums have been developed as
alternative delivery systems for therapeutic agents. Evidence from laboratory, clinical and community-based studies
suggests that appropriately formulated chewing gums may contribute to caries prevention, reduction of cariogenic bacteria
and maintenance of oral health when used alongside conventional preventive measures. This review summarizes the
composition, mechanisms of action, therapeutic applications, and oral health benefits of various chewing gum formulations
currently available.
Keywords :
Chewing Gum, Oral Health, Xylitol, Sorbitol, CPP–ACP, Remineralization, Medicated Chewing Gum.