Authors :
Dr. Venugopal Reddy. I; Dr. Rajesh Babu. M; Dr. Bhaskar Shenoy
Volume/Issue :
Volume 8 - 2023, Issue 4 - April
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/3Lti1DD
DOI :
https://doi.org/10.5281/zenodo.7889065
Abstract :
- Acinetobacter is an aerobic, pleomorphic,
non-motile bacillus that is Gram-negative. In the last 35
years, Acinetobacter baumannii has emerged as the most
problematic bacterium in the hospital and community
due to its genetic makeup and antibiotic resistance.
Infections of the skin, soft tissues, central nervous
system, and bones are on the rise due to strains that are
resistant to antibiotics and can survive for a long period.
This study aims to study the epidemiological and clinical
characteristics and antibiogram of different species of
Acinetobacter. Antimicrobial susceptibility testing was
performed at the Manipal hospital in Bangalore, India,
using VITEK 2 AST-N090 automated system for
amikacin, amoxicillin-clavulanate, cefepime,
ciprofloxacin, colistin, gentamicin, imipenem,
meropenem, piperacillin-tazobactam, tetracycline,
tigecycline and trimethoprim-sulfamethoxazole.
Ethics-related considerations were granted.
Acinetobacter species have emerged as a significant
offender in both the hospital and the community.
Predominance of infections among infants under one
month old, primarily those in neonatal intensive care
units, suggests that preterm and newborn infants are
more susceptible to acinetiobacter infections. Pneumonia
was the most frequent clinical manifestation in this
study, with risk factors such as long-term invasive
procedures, prolonged ventilation, and broad-spectrum
antibiotic use. Acinetobacter has become less susceptible
to antibiotics over time, and polymyxin is the only
therapeutic choice for MDR infections in environments
with restricted resources.
Colistin and polymixn were the most efficient
drugs, while carbapenems showed just 10% sensitivity.
Mortality rates ranged from 17% to 63%, with preterm
babies having increased mortality rates. Acinetobacter
infections in children are on the rise, mostly affecting
neonatal and paediatric intensive care units. A
multicentric study is needed to research the risk factors,
interventions, and antibiogram of the organisms.
Treatment costs increase due to resistance to oral
antibiotics. Acinetobacter strain identification using
culture and routine local antibiogram will help clinicians
understand the pattern of sensitivity for improved
treatment.
Keywords :
Acinetobacter, oral antibiotics, infections, Treatment, Clinicians.
- Acinetobacter is an aerobic, pleomorphic,
non-motile bacillus that is Gram-negative. In the last 35
years, Acinetobacter baumannii has emerged as the most
problematic bacterium in the hospital and community
due to its genetic makeup and antibiotic resistance.
Infections of the skin, soft tissues, central nervous
system, and bones are on the rise due to strains that are
resistant to antibiotics and can survive for a long period.
This study aims to study the epidemiological and clinical
characteristics and antibiogram of different species of
Acinetobacter. Antimicrobial susceptibility testing was
performed at the Manipal hospital in Bangalore, India,
using VITEK 2 AST-N090 automated system for
amikacin, amoxicillin-clavulanate, cefepime,
ciprofloxacin, colistin, gentamicin, imipenem,
meropenem, piperacillin-tazobactam, tetracycline,
tigecycline and trimethoprim-sulfamethoxazole.
Ethics-related considerations were granted.
Acinetobacter species have emerged as a significant
offender in both the hospital and the community.
Predominance of infections among infants under one
month old, primarily those in neonatal intensive care
units, suggests that preterm and newborn infants are
more susceptible to acinetiobacter infections. Pneumonia
was the most frequent clinical manifestation in this
study, with risk factors such as long-term invasive
procedures, prolonged ventilation, and broad-spectrum
antibiotic use. Acinetobacter has become less susceptible
to antibiotics over time, and polymyxin is the only
therapeutic choice for MDR infections in environments
with restricted resources.
Colistin and polymixn were the most efficient
drugs, while carbapenems showed just 10% sensitivity.
Mortality rates ranged from 17% to 63%, with preterm
babies having increased mortality rates. Acinetobacter
infections in children are on the rise, mostly affecting
neonatal and paediatric intensive care units. A
multicentric study is needed to research the risk factors,
interventions, and antibiogram of the organisms.
Treatment costs increase due to resistance to oral
antibiotics. Acinetobacter strain identification using
culture and routine local antibiogram will help clinicians
understand the pattern of sensitivity for improved
treatment.
Keywords :
Acinetobacter, oral antibiotics, infections, Treatment, Clinicians.
