Authors : Sushmitha J.; Thanya R. Shetty; Dr. Sitara Rathan; Dr. Muhsina C. H.; Dr. Ashaya M.; Dr. Rashmi K.; Dr. Raghavendra Kini

Volume/Issue : Volume 11 - 2026, Issue 10 - October

---

Google Scholar : https://tinyurl.com/329z3pxj

DOI : https://doi.org/10.38124/ijisrt/26Oct611

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

---

Abstract : Histopathologic interpretation can also be difficult if the lesion is vaporized instead of allowing for surgical excision due to thermal changes at the site.³,⁶ Treatment should therefore be determined on the clinical presentation, histopathologic findings, lesion characteristics and suitable follow-up.¹,⁷ CO₂laser treatment may serve as one option when deciding on an appropriate treatment modality, but should not take the place of histopathologic diagnosis or delay long-term follow-up.⁷

Keywords : Oral Leukoplakia; Carbon Dioxide Laser; Laser Surgery; Potentially Malignant Oral Disorders; Recurrence.

References :

1. Warnakulasuriya S, Johnson NW, van der Waal I. Nomenclature and classification of potentially Malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36(10):575–580. Doi:10.1111/j.1600-0714.2007.00582.x.
2. Mogedas-Vegara A, Hueto-Madrid JA, Chimenos-Küstner E, Bescós-Atín C. Oral leukoplakia treatment with the carbon dioxide laser: a systematic review of the literature. J Craniomaxillofac Surg. 2016;44(4):331–336. Doi:10.1016/j.jcms.2016.01.026.
3. Wilder-Smith P, Arrastia AM, Liaw LH, Berns M. Incision properties and thermal effects of three CO₂ lasers in soft tissue. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79(6):685–691.Doi:10.1016/S1079-2104(05)80300-2.
4. López-Jornet P, Camacho-Alonso F. Comparison of pain and swelling after removal of oral Leukoplakia with CO₂ laser and cold knife: a randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2013;18:e38–e44.
5. Brouns EREA, Baart JA, Karagozoglu KH, Aartman IHA, Bloemena E, van der Waal I. Treatment Results of CO₂ laser vaporisation in a cohort of 35 patients with oral leukoplakia. Oral Dis.2013;19(2):212–216.Doi:10.1111/odi.12007.
6. Deppe H, Mücke T, Hohlweg-Majert B, Hauck W, Wagenpfeil S, Hölzle F. Different CO₂ laser vaporization protocols for the therapy of oral precancerous lesions and precancerous conditions: A 10-year follow-up. Lasers Med Sci. 2012;27(1):59–63. Doi:10.1007/s10103-011-0910-5.
7. Lingen MW, Abt E, Agrawal N, et al. Evidence-based clinical practice guideline for the evaluation of potentially malignant disorders in the oral cavity: a report of the American Dental Association. J Am Dent Assoc. 2017;148(10):712–727.e10. doi:10.1016/j.adaj.2017.07.032.
8. Korkmaz M, et al. Evaluation of the effectiveness of the carbon dioxide (CO₂) laser in minor Oral surgery: a systematic review. J Lasers Med Sci. 2023. Doi:10.34172/jlms.2023.44.