Authors :
Vrushali Bhausaheb Nathe
Volume/Issue :
Volume 7 - 2022, Issue 11 - November
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3EzaO1B
DOI :
https://doi.org/10.5281/zenodo.7329128
Abstract :
Cognitive impairment and its severe form
dementia are progressively prevalent in older adults and
loom as a public health adversity unless effective
interventions are developed. Cognitive impairment is a
convergent trait caused by injury from an idiosyncratic
mix of four prevalent diseases (Alzheimer disease;
vascular brain injury; Lewy body diseases, such as
Parkinson disease and dementia with Lewy bodies; and
limbic-predominant age-related transactive response
DNA-binding protein 43 encephalopathy) that is balanced
by distinctly varying resilience, which is included of
reserve and reward. Brain regional damage from each of
these four predominant diseases is generated by the net
effect of injury and (mal)adaptive response and is
attended by characteristic lesions. Brain regional injury
is generated by the net effect of injury and (mal)adaptive
response. The extent to which signs and symptoms of such
damage occur is influenced by an fundamental flexibility
comprising reserve and reward. Finding personalized
interferences that target specific mechanisms of damage
likely yields the most effective therapies.
Keywords :
Cognitive Impairment, Traumatic Brain Injury, Brain, Dementia, Parkinson’s Disease, Alzheimer’s Disease, Mild Cognitive Impairment.
Cognitive impairment and its severe form
dementia are progressively prevalent in older adults and
loom as a public health adversity unless effective
interventions are developed. Cognitive impairment is a
convergent trait caused by injury from an idiosyncratic
mix of four prevalent diseases (Alzheimer disease;
vascular brain injury; Lewy body diseases, such as
Parkinson disease and dementia with Lewy bodies; and
limbic-predominant age-related transactive response
DNA-binding protein 43 encephalopathy) that is balanced
by distinctly varying resilience, which is included of
reserve and reward. Brain regional damage from each of
these four predominant diseases is generated by the net
effect of injury and (mal)adaptive response and is
attended by characteristic lesions. Brain regional injury
is generated by the net effect of injury and (mal)adaptive
response. The extent to which signs and symptoms of such
damage occur is influenced by an fundamental flexibility
comprising reserve and reward. Finding personalized
interferences that target specific mechanisms of damage
likely yields the most effective therapies.
Keywords :
Cognitive Impairment, Traumatic Brain Injury, Brain, Dementia, Parkinson’s Disease, Alzheimer’s Disease, Mild Cognitive Impairment.
