Authors :
Chandra Sekhar Tripathy; Dr. Santosh Kumar Behera; Dr. Anil Kumar; Dr. Santosh Kumar Panda; Dr. GauravGiri; Muhammad Akram; Dr. AsadollahAsadi
Volume/Issue :
Volume 7 - 2022, Issue 7 - July
Google Scholar :
https://bit.ly/3IIfn9N
Scribd :
https://bit.ly/3PDWqIZ
DOI :
https://doi.org/10.5281/zenodo.6865162
Abstract :
Colorectal cancer (CRC) is a type that
develops in the colon to anus segment of the elementary
canal. Is painful; acutely debilitating & fatality
becausing. Age; diet, lifestyle habits; occupational
stress; agrometeorology; bacteriums; virus have been
adduced as risk factors and a small percentage being
attributed to genetics etc.,. CRC is now a global threat.
However, physiologically the protein TNIK (TRAF2 And
NCK Interacting Kinase) is found to be widely
associated with CRC and is also over expressed.
Glycyrrhizaglabra is an herbal plant with lots of known
medicinal properties. Glycyrrhizaglabra has 45 known
phyto-compounds (PCs). In the present investigation all
the 45 PCs have been put to in silico processes including
docking and DFT (Density Functional Theory) analysis
to find out the PCs that best stop over-expression of the
TNIK protein in colorectal cancer. Glabroiso-flavanone
B and Glabridin are found to be champion molecules of
this plant against CRCs. Phytos are natural source hence
are peerless in drug discovery; functional food and in
synergistic therapeutics.
Keywords :
TNIK (TRAF2 And NCK Interacting Kinase), Docking, DFT, in silico, Wnt pathway.
Colorectal cancer (CRC) is a type that
develops in the colon to anus segment of the elementary
canal. Is painful; acutely debilitating & fatality
becausing. Age; diet, lifestyle habits; occupational
stress; agrometeorology; bacteriums; virus have been
adduced as risk factors and a small percentage being
attributed to genetics etc.,. CRC is now a global threat.
However, physiologically the protein TNIK (TRAF2 And
NCK Interacting Kinase) is found to be widely
associated with CRC and is also over expressed.
Glycyrrhizaglabra is an herbal plant with lots of known
medicinal properties. Glycyrrhizaglabra has 45 known
phyto-compounds (PCs). In the present investigation all
the 45 PCs have been put to in silico processes including
docking and DFT (Density Functional Theory) analysis
to find out the PCs that best stop over-expression of the
TNIK protein in colorectal cancer. Glabroiso-flavanone
B and Glabridin are found to be champion molecules of
this plant against CRCs. Phytos are natural source hence
are peerless in drug discovery; functional food and in
synergistic therapeutics.
Keywords :
TNIK (TRAF2 And NCK Interacting Kinase), Docking, DFT, in silico, Wnt pathway.
