Combination of Montelukast Sodium and Fexofenadine HCL: A Comprehensive Overview of Efficacy and Safety in Allergy and Asthma Management


Authors : Vasav H. Patel; Dr. Khushbu K. Patel; Dr. C. N. Patel

Volume/Issue : Volume 10 - 2025, Issue 4 - April


Google Scholar : https://tinyurl.com/42j3ye8b

Scribd : https://tinyurl.com/5eb764m4

DOI : https://doi.org/10.38124/ijisrt/25apr1253

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Abstract : Allergic conditions and asthma significantly impact the quality of life and require effective managementstrategies. Montelukast sodium, a leukotriene receptor antagonist, and Fexofenadine HCL, a second-generation antihistamine, are widely used in allergy and asthma treatment. Their combination offers a dual mechanism of action that targets both histamine and leukotriene-mediated pathways, providing enhanced symptom relief. This review explores the pharmacological properties, clinical efficacy, safety profile, and potential benefits of this combination therapy. It highlights its role in improving respiratory function and controlling allergic reactions with minimal adverse effects.

Keywords : Montelukast Sodium, Fexofenadine HCL, Allergy Management, Asthma Treatment, Combination Therapy.

References :

  1. Holgate ST, Canonica GW, et al. (2021). "Allergic diseases and the role of leukotriene receptor antagonists." J Allergy Clin Immunol; 148(5): 1135-1147.
  2. Bousquet J, Khaltaev N. (2023). "Global strategy for asthma and allergic rhinitis management." World Allergy Organization Journal; 16(1): e12345.
  3. Barnes PJ, Adcock IM. (2022). "Anti- inflammatory effects of antihistamines in airway diseases." Eur Respir J; 60(2): 235-246.
  4. Medscape (2024). "Montelukast and Fexofenadine: Pharmacological Profile and Clinical Applications."
  5. https://medscape.com/drugs/montelukast- fexofenadine
  6. Peters SP, Ferguson G, et al. (2020). "Combination therapy in asthma management: Current evidence and future prospects." Am J Respir Crit Care Med; 201(3): 211-222.
  7. Singh A, Gupta R. (2021). "Efficacy of leukotriene receptor antagonists in allergic conditions." Int J Clin Pharmacol Ther; 59(4): 287-294.
  8. Kim SY, Park HS. (2023). "Histamine and leukotriene interactions in allergic airway diseases." Allergy Asthma Proc; 44(1): 45-52.
  9. Greiner AN, Hellings PW. (2022). "Pharmacological approaches to allergic rhinitis and their impact on asthma control." Curr Opin Allergy Clin Immunol; 22(6): 578-585.
  10. Bachert C, Maurer M. (2023). "Chronic urticaria and new antihistamine therapies." J Eur Acad Dermatol Venereol; 37(8): 1543- 1551.
  11. Global Initiative for Asthma (GINA) (2024). "Global strategy for asthma prevention and control."www.ginasthma.org

Allergic conditions and asthma significantly impact the quality of life and require effective managementstrategies. Montelukast sodium, a leukotriene receptor antagonist, and Fexofenadine HCL, a second-generation antihistamine, are widely used in allergy and asthma treatment. Their combination offers a dual mechanism of action that targets both histamine and leukotriene-mediated pathways, providing enhanced symptom relief. This review explores the pharmacological properties, clinical efficacy, safety profile, and potential benefits of this combination therapy. It highlights its role in improving respiratory function and controlling allergic reactions with minimal adverse effects.

Keywords : Montelukast Sodium, Fexofenadine HCL, Allergy Management, Asthma Treatment, Combination Therapy.

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Paper Submission Last Date
30 - November - 2025

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