The risk of developing epilepsy in patients with gliomas or neuroepithelial tumours is extremely significant. Low-grade and high-grade gliomas are the two types of gliomas. Low-grade brain tumours, as well as tumours located in the temporal and insular cortex, have a higher proclivity for developing epilepsy. Seizure control is much improved by surgical treatment of the tumour, particularly gross tumour removal, especially in neuroglial tumours. Low-grade gliomas are more likely to cause refractory epilepsy, with 30–35 percent experiencing it. The therapy of combined drug-induced gingival expansion in a patient surgically treated for low-grade glioma is described in this case report.