Authors :
Palak Kakkar
Volume/Issue :
Volume 10 - 2025, Issue 10 - October
Google Scholar :
https://tinyurl.com/2vrhfnwe
Scribd :
https://tinyurl.com/3h2kxbbw
DOI :
https://doi.org/10.38124/ijisrt/25oct440
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Note : Google Scholar may take 30 to 40 days to display the article.
Abstract :
Antimicrobial resistance (AMR) represents a paramount global health threat, responsible for millions of deaths
annually and jeopardizing the foundations of modern medicine. Antimicrobial stewardship (AMS) programs are a critical
strategy to combat this crisis, particularly in community settings where the majority of antimicrobials are consumed. This
systematic review aims to critically evaluate and compare the evidence for the effectiveness of three core community AMS
interventions—educational, audit-and-feedback, and dispensing-related—in two distinct contexts: The United Kingdom
(UK) as a high-income country model, and Low- and Middle-Income Countries (LMICs). A systematic search of PubMed,
Cochrane CENTRAL, and Embase was conducted for studies evaluating these interventions. The synthesis reveals that
intervention effectiveness is profoundly context-dependent. In the UK, systematic, data-driven audit-and-feedback has
proven highly effective in reducing antibiotic prescribing in primary care, complemented by structured, pharmacist-led
dispensing interventions incentivized through national schemes. Conversely, broad educational campaigns have shown
limited impact. In LMICs, multifaceted educational interventions that build foundational knowledge among a wide range
of formal and informal healthcare providers are the most impactful strategy. Pharmacist-led audit-and-feedback shows
promise but faces significant sustainability challenges. The community pharmacist emerges as a pivotal figure in both
settings, though their role shifts from an optimizer within a regulated system in the UK to a primary point of care and de
facto prescriber in many LMICs. The evidence base is limited by methodological heterogeneity and a lack of studies
reporting on clinical and microbiological outcomes. Effective community AMS requires context-specific strategies that align
with existing health system infrastructure, regulatory capacity, and human resources. Future research must prioritize
rigorous, long-term studies evaluating the sustainability and clinical impact of AMS interventions to guide global policy.
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Antimicrobial resistance (AMR) represents a paramount global health threat, responsible for millions of deaths
annually and jeopardizing the foundations of modern medicine. Antimicrobial stewardship (AMS) programs are a critical
strategy to combat this crisis, particularly in community settings where the majority of antimicrobials are consumed. This
systematic review aims to critically evaluate and compare the evidence for the effectiveness of three core community AMS
interventions—educational, audit-and-feedback, and dispensing-related—in two distinct contexts: The United Kingdom
(UK) as a high-income country model, and Low- and Middle-Income Countries (LMICs). A systematic search of PubMed,
Cochrane CENTRAL, and Embase was conducted for studies evaluating these interventions. The synthesis reveals that
intervention effectiveness is profoundly context-dependent. In the UK, systematic, data-driven audit-and-feedback has
proven highly effective in reducing antibiotic prescribing in primary care, complemented by structured, pharmacist-led
dispensing interventions incentivized through national schemes. Conversely, broad educational campaigns have shown
limited impact. In LMICs, multifaceted educational interventions that build foundational knowledge among a wide range
of formal and informal healthcare providers are the most impactful strategy. Pharmacist-led audit-and-feedback shows
promise but faces significant sustainability challenges. The community pharmacist emerges as a pivotal figure in both
settings, though their role shifts from an optimizer within a regulated system in the UK to a primary point of care and de
facto prescriber in many LMICs. The evidence base is limited by methodological heterogeneity and a lack of studies
reporting on clinical and microbiological outcomes. Effective community AMS requires context-specific strategies that align
with existing health system infrastructure, regulatory capacity, and human resources. Future research must prioritize
rigorous, long-term studies evaluating the sustainability and clinical impact of AMS interventions to guide global policy.