Comparative Effects of Some Common Vegetable Oils on Lipid Profile and Liver Function in Male Wistar Rats

Authors : Umezulike Anulika Jacinta; Maduka Stephen Ozoemena; Njoku-Oji Nancy Njideka; OkonudoPeter O; Nwaefulu Kester Eluemunor; Mmaju ChidimmaIfeyinwa; Chukwukaeme Chidimma Winifred; Ezeani Emmanuel Ifeakandu

Volume/Issue : Volume 6 - 2021, Issue 12 - December

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Vegetable oils, a major source of lipids form essential part of the human diet, It is second source of energy after carbohydrates. Dietary oils high in unsaturated fatty acids have been correlated with the incidence of cardiovascular disease. This study investigated the comparative effects of some common vegetable oils on lipid profile and liver function in male wistar rats. 25 male wistar rats were divided into 5 groups (n=5). Group 1 served as control and were given rats feed and water only, Groups 2, 3, 4 and 5 served as the test groups and were administered 2ml/kg/day of palm, coconut, olive and soya oils respectively. All animals had feed and water ad libitum for 8 weeks. Body weight, relative liver weight, lipid profile, serum liver enzymes and histopathological examination of the liver tissue were compared among different groups. Results revealed a significantly (p < 0.05) elevated body weight in all the groups when initial and final weight was compared. Group 4 significantly elevated relative liver weight and triglyceride level, while group 3 significantly decreased total cholesterol and LDL-C. However, HDL-C and liver enzymeswere insignificantly changed in all treated groups compared to control and with one another. Histopathological examination revealed a moderate impairment of hepatic tissues in all the oil treated groups compared to control. This study concludes that consumption of these vegetable oils for longer duration increase body weight, and impairs liver function. Coconut oil however, improved lipid profile while olive oil showed a therogenic property than other oils.

Keywords : vegetable oil, lipid profile, coconut, palm, liver


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30 - June - 2023

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