Authors :
Dr. Sejal Kumarpal Munoyath; Dr Kavitha Prasad; Dr. K. Ranganath
Volume/Issue :
Volume 8 - 2023, Issue 5 - May
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://tinyurl.com/2czfcycf
DOI :
https://doi.org/10.5281/zenodo.8163179
Abstract :
Purpose of the study: Very often patients present for
treatment with acute orofacial infections which have
either beeninadequately treated or patients have
inappropriately taken multiple courses of antibiotics
without resolution of their problem. We wanted to study
the efficacy of two basic antibiotics which were effective
against beta-lactamase producing organisms, that is
Amoxycillin-Clavulinic acid and Clindamycin along with
local measures for these resistant infections.
This study is conducted to compare the efficacy of
Clindamycin and Amoxicillin -Clavulinic acid in the
treatment of resistant orofacial infections and propose
the use of these drugs empirically as first line of therapy
To evaluate the efficacy of Clindamycin which is in
limited use for severe odontogenic infections and in
infections spreading to the bone. To propose the use of
antibiotic empirically in resistant infection.
Patients and Methods: Patients with one or more fascial
space infections presenting with draining sinus, cellulitis
or a consolidated swelling ,patients who received beta
lactam antibiotics for three days or more and with
unresolved infections were included in this study. Of the
forty patients included in the study, twenty received
Amoxicillin Clavulinic acid and twenty received
Clindamycin .The efficacy was compared based on
improvement in clinical symptoms with the use of
various parameters like duration of pain, swelling,
trismus, pus discharge.
Results: In our study both Amoxicillin Clavulinic acid
and Clindamycin showed similar good results with
complete resolution of infection. The mandibular spaces
were more frequently involved as compared to maxilla.
The number of days pus discharge in the Clindamycin
group was less ( < 3days ) and the improvement of
mouth opening was better; both the results being
statistically significant.
Conclusion: With this study we conclude that both
Amoxicillin Clavulinic acid and Clindamycin have
proved to be equally effective in resistant orofacial
infections. Clindamycin can be used as an empiric drug
in resistant orofacial infections and in infections that
have potentially spread to bone. For practical
implications in patients with acute orofacial infections,
infections involving bone and those infections that have
not responded to inadequate/inappropriate treatment,
Clindamycin can be preferred over Amoxicillin-
clavulanate. When Amoxicillin -Clavulanate is used, it
may be better to combine it with Metronidazole
Keywords :
Odontogenic infection, resistant orofacial infection, Amoxicillin clavulinic acid, Clindamycin, empirical antibiotics.
Purpose of the study: Very often patients present for
treatment with acute orofacial infections which have
either beeninadequately treated or patients have
inappropriately taken multiple courses of antibiotics
without resolution of their problem. We wanted to study
the efficacy of two basic antibiotics which were effective
against beta-lactamase producing organisms, that is
Amoxycillin-Clavulinic acid and Clindamycin along with
local measures for these resistant infections.
This study is conducted to compare the efficacy of
Clindamycin and Amoxicillin -Clavulinic acid in the
treatment of resistant orofacial infections and propose
the use of these drugs empirically as first line of therapy
To evaluate the efficacy of Clindamycin which is in
limited use for severe odontogenic infections and in
infections spreading to the bone. To propose the use of
antibiotic empirically in resistant infection.
Patients and Methods: Patients with one or more fascial
space infections presenting with draining sinus, cellulitis
or a consolidated swelling ,patients who received beta
lactam antibiotics for three days or more and with
unresolved infections were included in this study. Of the
forty patients included in the study, twenty received
Amoxicillin Clavulinic acid and twenty received
Clindamycin .The efficacy was compared based on
improvement in clinical symptoms with the use of
various parameters like duration of pain, swelling,
trismus, pus discharge.
Results: In our study both Amoxicillin Clavulinic acid
and Clindamycin showed similar good results with
complete resolution of infection. The mandibular spaces
were more frequently involved as compared to maxilla.
The number of days pus discharge in the Clindamycin
group was less ( < 3days ) and the improvement of
mouth opening was better; both the results being
statistically significant.
Conclusion: With this study we conclude that both
Amoxicillin Clavulinic acid and Clindamycin have
proved to be equally effective in resistant orofacial
infections. Clindamycin can be used as an empiric drug
in resistant orofacial infections and in infections that
have potentially spread to bone. For practical
implications in patients with acute orofacial infections,
infections involving bone and those infections that have
not responded to inadequate/inappropriate treatment,
Clindamycin can be preferred over Amoxicillin-
clavulanate. When Amoxicillin -Clavulanate is used, it
may be better to combine it with Metronidazole
Keywords :
Odontogenic infection, resistant orofacial infection, Amoxicillin clavulinic acid, Clindamycin, empirical antibiotics.
