Authors :
Most. Reshma Akter; Md. Shafiqul Islam; Md. Masud Rana
Volume/Issue :
Volume 5 - 2020, Issue 11 - November
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3gv8DiQ
Abstract :
Metformin, a biguanide derivatives, is the
first-line drug for the treatment of type-2 diabetes
mellitus, particularly in overweight and obese people.
Numerous brands of Metformin HCl tablets (500mg) are
available in the Bangladeshi market. The objective of
this study was to evaluate the physicochemical
parameters of seven brands of Metformin HCl tablets
available in the market. The tested brands of Metformin
HCl tablets were assessed through the evaluation of
official standards such as weight variation, hardness,
friability, disintegration time, dissolution rate and
potency to quantify the quality parameters.
Keywords :
Metformin Hcl, Hardness, Friability, Disintegration, Dissolution, Potency
Metformin, a biguanide derivatives, is the
first-line drug for the treatment of type-2 diabetes
mellitus, particularly in overweight and obese people.
Numerous brands of Metformin HCl tablets (500mg) are
available in the Bangladeshi market. The objective of
this study was to evaluate the physicochemical
parameters of seven brands of Metformin HCl tablets
available in the market. The tested brands of Metformin
HCl tablets were assessed through the evaluation of
official standards such as weight variation, hardness,
friability, disintegration time, dissolution rate and
potency to quantify the quality parameters.
Keywords :
Metformin Hcl, Hardness, Friability, Disintegration, Dissolution, Potency
