Authors :
Reeta Maurya; Manodeep Sen; Alok Kumar Singh
Volume/Issue :
Volume 8 - 2023, Issue 2 - February
Google Scholar :
https://bit.ly/3TmGbDi
Scribd :
https://bit.ly/3JEjnL4
DOI :
https://doi.org/10.5281/zenodo.7754557
Abstract :
Patients of oral cancer receiving
Chemo-radiotherapy often develop oral mucosit is due to
influence in imbalance of oral flora which colonize over
it. These patients are at high risk for oral bacterial and
yeast infection.
OBJECTIVES: This study was aimed to evaluate the
effect of radiation on oral swab and salivary bacterial
and yeast flora in patients with oral cancer under
chemo-radiotherapy.
PATIENTS AND METHODS: Swab and saliva samples
were collected before RT and post RT from each of the
77 oral cancer patients, who were advised RT and
Chemotherapy. Bacterial and yeast culture and growth
was done using standard techniques.
RESULTS: Out of 77 patients 89.6% were male and
maximum patients were from age group 61-70 years.
64% patients were tobacco chewers. Oropharynx cancer
(29.8%) was found to be most common followed by
tongue cancer (23.4%).A definitive decrease in
Staphylococcus aureus and E. Faecium was observed in
both swab and saliva samples post radiotherapy,
Citrobacter was found to be significantly decreased in
saliva sample post radio therapy while high prevalence
of Candida colonisation in the saliva sample was
observed post RT.
CONCLUSION: The present study showed that changes
in the oral and/or systemic environment due to cancer
therapy can result in growth of many bacterial and
fungal species in oral cavity that can lead to clinical
bacterial/fungal infection.
Keywords :
Chemo-Radiotherapy, Oral Cancer, Oral Microorganisms
Patients of oral cancer receiving
Chemo-radiotherapy often develop oral mucosit is due to
influence in imbalance of oral flora which colonize over
it. These patients are at high risk for oral bacterial and
yeast infection.
OBJECTIVES: This study was aimed to evaluate the
effect of radiation on oral swab and salivary bacterial
and yeast flora in patients with oral cancer under
chemo-radiotherapy.
PATIENTS AND METHODS: Swab and saliva samples
were collected before RT and post RT from each of the
77 oral cancer patients, who were advised RT and
Chemotherapy. Bacterial and yeast culture and growth
was done using standard techniques.
RESULTS: Out of 77 patients 89.6% were male and
maximum patients were from age group 61-70 years.
64% patients were tobacco chewers. Oropharynx cancer
(29.8%) was found to be most common followed by
tongue cancer (23.4%).A definitive decrease in
Staphylococcus aureus and E. Faecium was observed in
both swab and saliva samples post radiotherapy,
Citrobacter was found to be significantly decreased in
saliva sample post radio therapy while high prevalence
of Candida colonisation in the saliva sample was
observed post RT.
CONCLUSION: The present study showed that changes
in the oral and/or systemic environment due to cancer
therapy can result in growth of many bacterial and
fungal species in oral cavity that can lead to clinical
bacterial/fungal infection.
Keywords :
Chemo-Radiotherapy, Oral Cancer, Oral Microorganisms
