Objective: The aim of the study was to evaluate the efficacy of triple osteopathic manipulative method and open kinematic chain exercises in individuals with pes anserine bursitis.  Methodology: Two groups of 30 patients each received 30 patients were randomly assigned. 15 patients make up Group-A (open kinematic exercises). There are 15 patients in Group-B (triple osteopathic manipulative treatment). Pre-assessment was completed for both groups before to the start of the intervention programme using the outcome measures of VAS and KNEE ROM (GONIOMETER).  Procedure: Group-A underwent open kinematic chain exercises during the course of a 6-week intervention programme, while Group-B received triple osteopathic manipulative therapy. Assessments were done following the 6-week intervention.  Results: Both groups A and B did not exhibit any statistically significant differences between pre- and post-intervention, according to the data analysis. Comparing the mean values of Group A and B reveals that both are efficient in treating pes anserine bursitis.  Conclusion: These results show that triple osteopathic manipulative treatment and open kinematic chain exercises are equally beneficial at easing pain and restoring range of motion in people with pes anserine bursitis.