Authors : Dr. Srishti Salunke; Dr. Anuj Dadhich; Dr. Seemit Shah; Dr. Harish Saluja; Dr. Pulkit Khandelwal; Dr. Kedar Kawsankar; Dr. Megha Kiran; Dr. BL Himaja Reddy

Volume/Issue : Volume 8 - 2023, Issue 11 - November

Google Scholar : https://tinyurl.com/ycytjh9u

Scribd : https://tinyurl.com/4cc5wskd

DOI : https://doi.org/10.5281/zenodo.10212093

Abstract : Background: Ropivacaine is a long-acting amide local anesthetic agent and firstproduced as a pure enantiomer. It produces effects similar to other local anesthetics via reversible inhibition of sodium ion influx in nerve fibers. Ropivacaine is lesslipophilic than bupivacaine and is less likely to penetrate large myelinated motorfibers, resulting in a relatively reduced motor blockade. Thus, ropivacaine has agreater degree of motor sensory differentiation, which could be useful when motorblockade is undesirable. The reduced lipophilicity is also associated with decreasedpotential for central nervous system toxicity and cardiotoxicity. The drug displayslinear and dose proportional pharmacokinetics (up to 80 mg administeredintravenously). It is metabolized extensively in the liver and excreted in urine. Thepresent article details the clinical applications of ropivacaine and its current place asa local anesthetic in the group. Materials and methods: The research was undertaken following approval from the institutional ethics committee and spanned a duration of two years, during which a comprehensive evaluation was performed on 52 participants. Results: A bigger sample size should beconsidered for more specific comparison. Bupivacaine has a very long duration ofaction which is not required for minor surgical procedure whereas Ropivacaine alsois long acting but less than Bupivacaine which is perfect for more time requiredprocedures and post –operative analgesia. Ropivacaine has vasoconstrictive natureand the difference was seen bleeding was more when Bupivacaine was used. In ourstudy no adverse effects were encountered when we used both the drugs butBupivacaine is cardiotoxic in nature and changes in blood pressure and heart ratewere seen when Bupivacaine was used so Ropivacaine can be considered to be usedin Oral and Maxillofacial surgery Conclusion: So, to conclude, my opinion when 0.2% Ropivacaine and 0.25%Bupivacaine was compared in sample size 52, 0.2% Ropivacaine was better in termsof early onset and duration than 0.25% Bupivacaine.

Keywords : Anesthesia, Local anaesthetic, Ropivacaine, Bupivacaine.