Ultrasonic scaling is a routinely performed procedure in dental practice. The fear of pain during treatment has been identified as a major factor in preventing patients from seeking dental care. To overcome this, desensitizing agents are used. This study aims to compare the effectiveness of 2-Hydroxy Ethyl Methacrylate and potassium nitrate containing gel and lidocaine containing gel on hypersensitivity during ultrasonic scaling. Material and methods: 30 patients were enrolled in this split mouth study. One side was applied with Shield Activ gel and the other with lignocaine gel. VAS scores were measured at baseline and post application. The mean VAS score was significantly better in both groups when compared to baseline. Lignocaine gel shows better results compared to Shield Activ gel. 2-hydroxy ethyl methacrylate and potassium nitrate-containing gel and lignocaine hydrochloride gel both help in significant reduction of pain during ultrasonic scaling.