Authors : A. A. Sivabalan; Tamilselvan C.; Tamizharasi A.; Vignesh N.; Vigneshwaran S.; Vinodini S.; P. Vaijayanthimala; B. Sangameswaran

Volume/Issue : Volume 11 - 2026, Issue 8 - August

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Google Scholar : https://tinyurl.com/5asdr62e

DOI : https://doi.org/10.38124/ijisrt/26aug1210

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

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Abstract : Chemical stability under both harsh and everyday storage conditions is a decisive factor in whether an antidepressant tablet can be relied upon to deliver a consistent dose over its shelf life. This work compares how five commonly dispensed antidepressants – Fluoxetine Hydrochloride, Duloxetine Hydrochloride, Amitriptyline Hydrochloride, Selegiline Hydrochloride and Mirtazapine – behave when pushed hard by stress testing and, separately, when simply left on the bench for a week. Absorbance loss at each drug's own wavelength of maximum absorption was tracked by UV-Visible spectrophotometry after acid, base, peroxide, heat and light exposure, and again, day by day, under ordinary room conditions.

Keywords : Antidepressants; UV-Visible Spectrophotometry; Forced Degradation; Stability Testing; Fluoxetine; Duloxetine; Amitriptyline; Selegiline; Mirtazapine.

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