Patients in the ICU experience hemodynamic disorders, hemodynamics is the flow of blood in the body's circulatory system, either through the magna circulation (large circulation) or parva circulation (circulation in the lungs). Under normal conditions, hemodynamics will always be maintained in a physiological condition with neurohormonal control. The combination of opioids and benzodiazepines is often used in the induction and maintenance of anesthesia. Hemodynamic changes after the combination of the two drugs caused a significant decrease in the function of the cardiovascular system. Until now, studies assessing the effect of sedative drugs on cardiac output are still very rare. Destination: This study aims to determine the comparison of fentanyl combined with dexmedetomidine and fentanyl combined with midazolam on cardiac output using USCOM in ICU patients at RSUP.H.Adam Malik Medan.

Keywords : Fentanyl, Dexmedetomidine, Midazolam, Cardiac Output, ICU.