To compare safety and efficacy of pregabalin and
desvenlafaxine respectively for treating Neuropathic
04 patients were entered into a prospective
observational study of pregabalin and desvenlafaxine in
neuropathic pain for 6 months. Patients were randomly
arranged into 2 groups, 52 patients received pregabalin
and other group of 52 patients received desvenlafaxine.
The initialassessement were made during the first visit
and two subsequent reviews were done in 2 months
interval, up to 6 months. Visual analogue pain scores,
incidence of side effects were measured.
The pain scores(mean±S.D.) were 5.37±1.14 and
6.7±1.39 respectively for desvenlafaxine and
pregabalin.The low pain score of desvenlafaxine was
associated with prolonged pain relief. There were
pronounced differences in incidence of side effect
between the two drugs: pregabalin, 36.5% compared to
The study findings revealed that desvenlafaxine is
more safe and efficacious than pregabalin. Thus this
study recommends the use of desvenlafaxine for
neuropathic pain over pregabalin
Keywords : Desvenlafaxine, Pregabalin, pain, Neuropathic pain.