 Introduction: Increased blood sugar levels in patients undergoing surgery and anesthesia is one of the important problems in perioperative management, so that the selection of appropriate induction drugs is needed in patients with hyperglycemia.  Objective: This study aims to determine the comparison of blood sugar levels when induced using a combination of ketamine and propofol (ketofol) and single ketamine in patients undergoing total intravenous general anesthesia at H. Adam Malik General Hospital of Medan.  Method: This research is an experimental study with double blind. The study was conducted at the H. Adam Malik General Hospital of Medan from June to July 2019. The total sample obtained was 62, of which 31 samples were given ketofol treatment, while the other 31 samples were given ketamine treatment. The blood sugar level was then measured at 5, 10, 15, and 20 minutes after induction. Data collection was done using questionaires and blood sugar level sticks.  Results: The mean value of blood sugar levels in the group given ketamine increased compared to the group given ketofol after observation for 5 minutes (T1) and 10 minutes (T2) but not significant, whereas in T3 (15 minutes) and T4 (20 minutes) a significant difference was found.  Conclusion: The combination of intravenous ketamine and propofol (ketofol) and single ketamine only has an influence on the blood sugar levels in patients undergoing total intravenous general anesthesia, where ketamine further increases blood sugar levels when compared to ketofol.

Keywords : Hyperglycemia, Ketofol, Ketamine, Blood Sugar Levels