Comparison of the Effectiveness of Hyperbaric Bupivacaine and Isobaric Levobupivacaine for Spinal Anesthesia for Abdominal and Lower Extremity Surgery

Authors : Farilsah Hakim, Achsanuddin Hanafie, Dadik Wahyu Wijaya

Volume/Issue : Volume 5 - 2020, Issue 1 - January

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Bupivacaine has often been used in spinal anesthesia because of its relatively fast onset, long working hours and good sensory and motor block effects. Levobupivacaine is also reported to have more minimal side effects compared to bupivacaine. This study aims to compare the effectiveness between the use of hyperbaric bupivacaine with isobaric levobupivacaine for spinal anesthesia of abdominal surgery and lower extremity. Effectiveness was assessed based on the onset, working duration, and side effects of hyperbaric bupivacaine 0.5% 15 mg compared with isobaric levobupivacaine 0.5% 15 mg. The study involved by 62 patients who underwent abdominal and lower limb surgery. Patients were divided into two groups, each consisting of 31 people. The first group (A) received hyperbaric bupivacaine 15 mg 0.5% and the second group (B) received isobaric levobupivacaine 15 mg 0.5%. From the results of this study it was found that the average sensory action of hyperbaric bupivacaine 15 mg 0.5% (Marcain) was slightly faster than levobupivacaine 15 mg 0.5% (Levica), which was 172.39 seconds compared to 249.03 seconds to reach the sensorial block of Th6 for the administration of spinal anesthesia, with a p-value <0.05 (p = 0.008). As for the average duration of analgesia it was found that isobaric levobupivacaine 15 mg 0.5% took longer than hyperbaric bupivacaine 15 mg 0.5%, which was 334.56 minutes for levobupivacaine and 221 minutes for bupivacaine, with p-value <0.05 ( p = 0.001). The side effects of isobaric levobupivacaine 0.5% 15 mg was less than hyperbaric bupivacaine 0.5% 15 mg for spinal anesthesia.

Keywords : Bupivacaine, Levobupivacaine, Spinal Anesthesia.


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