Authors : Dr. Sharath Kumar Shetty B.; Dr. Kavya G A

Volume/Issue : Volume 10 - 2025, Issue 6 - June

Google Scholar : https://tinyurl.com/3aafsvww

DOI : https://doi.org/10.38124/ijisrt/25jun765

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Background and Objective: One of the primary concerns for orthodontic patients is the duration of treatment. Shortening this time involves carefully managing the treatment process from the very beginning. 1 Studies have shown that bone resorption is the key factor that limits the speed of tooth movement. As a result, techniques that enhance osteoclast activity can help increase the pace of orthodontic tooth movement. Several methods aimed at accelerating orthodontic treatment have been developed, though their outcomes have been inconsistent. Injectable platelet-rich fibrin (i-PRF) and micro-osteoperforations (MOP) are among the least invasive surgical techniques, as MOP does not require raising a full-thickness flap. Both approaches promote the activity of osteoclasts and osteoblasts. Notably, i-PRF significantly increases the levels of RANKL, MMP8, and IL-1β—key factors involved in bone remodeling. This study aimed to compare the effectiveness of i-PRF and MOP in enhancing the rate of space closure during en masse retraction of the maxillary anterior teeth.  Methods: Twenty-four patients undergoing orthodontic treatment at K.V.G. Dental College and Hospital, all requiring extraction of the maxillary first premolars, were selected and divided into two groups of 12: the i-PRF group and the MOP group. In the i-PRF group, injections were administered into the distobuccal and distolingual periodontal ligament spaces of the maxillary canines twice—once immediately before the start of en masse retraction and again at the second week of retraction. Local anesthesia was used prior to the injections to ensure patient comfort.  Results: The rate of space closure was similar in i-PRF group anf MOP group and the difference between the two groups was not statistically significant...  Interpretation and Conclusion: It was concluded that both injectable platelet rich fibrin and MOP minimally invasive procedure had similar rate of tooth movement which could be an effective enhancing orthodontic treatment efficiency by accelerating tooth movement.

Keywords : En-masse retraction; injectable platelet rich fibrin; Microosteoperforation; accelerated orthodontics; orthodontic tooth movement.

References :

1. Taori K, Niranjane P.Effect of Injectable Platelet-Rich Fibrin and Micro- Osteoperforation on Accelerated Orthodontic Tooth Movement: Protocol for a Split- Mouth Randomised Clinical Trial. Journal of Clinical & Diagnostic Research. 2023 Jul 1;17(7).
2. Fink DF, Smith RJ. The duration of orthodontic treatment. American Journal of Orthodontics and Dentofacial Orthopedics. 1992Jul1;102(1):45-51
3. Accelerated ortho- Shenava S, Nayak KU, Bhaskar V, Nayak A. Accelerated orthodontics-a review. International Journal of Scientific Study. 2014Feb;1(5):35-9.
4. Erdur EA, Karakaslı K, Oncu E, Ozturk B, Hakkı S. Effect of injectable platelet- rich fibrin (i-PRF) on the rate of tooth movement: A randomized clinical trial. The Angle Orthodontist. 2021 May 1;91(3):285-92.
5. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 2006Mar1;101(3): e37-44.
6. Wang X, Zhang Y, Choukroun J, Ghanaati S, Miron RJ. Effects of an injectable platelet-rich fibrin on osteoblast behavior and bone tissue formation in comparison to platelet-rich plasma. Platelets. 2018 Jan2; 29(1):48-55.
7. Alikhani M, Raptis M, Zoldan B, Sangsuwon C, Lee YB, Alyami B, Corpodian C, Barrera LM, Alansari S, Khoo E, Teixeira C. Effect of micro-osteoperforations on the rate of tooth movement. American Journal of Orthodontics and Dentofacial Orthopedics. 2013 Nov 1;144(5):639-48.
8. Alikhani M, Chou MY, Khoo E, Alansari S, Kwal R, Elfersi T, et al. Age- dependent biologic response to orthodontic forces. Am J Orthod Dentofacial Orthop. 2018 May;153(5):632–44.
9. Skidmore KJ, Brook KJ, Thomson WM, Harding WJ. Factors influencing treatment time in orthodontic patients. Am J Orthod Dentofacial Orthop.2006 Feb;129(2):230–8.
10. Alikhani M, Raptis M, Zoldan B, Sangsuwon C, Lee YB, Alyami B, et al. Effect of micro-osteoperforations on the rate of tooth movement. Am J Orthod Dentofacial Orthop. 2013 Nov;144(5):639–48.
11. Youssef M, Ashkar S, Hamade E, Gutknecht N, Lampert F, Mir M. The effect of
12. low-level laser therapy during orthodontic movement: a preliminary study. Lasers Med Sci. 2007 Nov 28;23(1):27–33.
13. Bartzela T, Türp JC, Motschall E, Maltha JC. Medication effects on the rate of orthodontic tooth movement: A systematic literature review. Am J Orthod Dentofacial Orthop. 2009 Jan;135(1):16–26.
14. Long H, Pyakurel U, Wang Y, Liao L, Zhou Y, Lai W. Interventions for accelerating orthodontic tooth movement: A systematic review. Angle Orthod. 2013 Jan;83(1):164–71.
15. Yu H, Jiao F, Wang B, Shen SG. Piezoelectric Decortication Applied in Periodontally Accelerated Osteogenic Orthodontics: J Craniofac Surg. 2013 Sep;24(5):1750–2.
16. Goswami P, Chaudhary V, Arya A, Verma R, Vijayakumar G, Bhavani M. Platelet-Rich Fibrin (PRF) and its Application in Dentistry: A Literature Review. J Pharm Bioallied Sci. 2024 Feb;16(Suppl 1):S5–7.
17. Frost HM (1983) The regional acceleratory phenomenon: a review. Henry Ford Hosp Med J 31(1):3–9
18. Alikhani M, Raptis M, Zoldan B, Sangsuwon C, Lee YB, Alyami B, Corpodian C, Barrera LM, Alansari S, Khoo E, Teixeira C. Effect of micro-osteoperforations on the rate of tooth movement. American Journal of Orthodontics and Dentofacial Orthopedics. 2013 Nov 1;144(5):639-48.
19. Feizbakhsh M, Zandian D, Heidarpour M, Farhad SZ, Fallahi HR. The use of microosteoperforation concept for accelerating differential tooth movement. Journal of the World Federation of Orthodontists. 2018 Jun 1;7(2):56-60.
20. Feizbakhsh M, Zandian D, Heidarpour M, Farhad SZ, Fallahi HR. The use of microosteoperforation concept for accelerating differential tooth movement. Journal of the World Federation of Orthodontists. 2018 Jun 1;7(2):56-60.
21. Teixeira CC, Khoo E, Tran J, Chartres I, Liu Y, Thant LM, Khabensky I, Gart LP, Cisneros G, Alikhani M. Cytokine expression and accelerated tooth movement. Journal of dental research. 2010 Oct;89(10):1135-41.
22. Sivarajan S, Doss JG, Papageorgiou SN, Cobourne MT, Wey MC. Mini-implant supported canine retraction with micro-osteoperforation: a split-mouth randomized clinical trial. The Angle Orthodontist. 2019 Mar 1;89(2):183-9.
23. Cheung T, Park J, Lee D, Kim C, Olson J, Javadi S, Lawson G, McCabe J, Moon W, Ting K, Hong C. Ability of mini-implant–facilitated micro-osteoperforations to accelerate tooth movement in rats. American Journal of Orthodontics and Dentofacial Orthopedics. 2016 Dec 1;150(6):958-67
24. Sugimori T, Yamaguchi M, Shimizu M, Kikuta J, Hikida T, Hikida M, Murakami Y, Suemitsu M, Kuyama K, Kasai K. Micro-osteoperforations accelerate orthodontic tooth movement by stimulating periodontal ligament cell cycles. American Journal of Orthodontics and Dentofacial Orthopedics. 2018 Dec 1;154(6):788-96.