Authors :
Bhargavi V.; Manjula G. S.; Rupesh Kumar; Imrongnaro; Namgyal Dolma; Gopi M.
Volume/Issue :
Volume 11 - 2026, Issue 7 - July
Google Scholar :
https://tinyurl.com/45mvk78v
Scribd :
https://tinyurl.com/yu5wf6k9
DOI :
https://doi.org/10.38124/ijisrt/26jul1435
Note : A published paper may take 4-5
working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and
ResearchGate.
Abstract :
Malva sylvestris L. is a medicinal plant from the Malvaceae family that is found across different regions,
including parts of Europe, North Africa, and Asia. It has been traditionally used for managing conditions related to
inflammation, digestion, and the respiratory system, mainly due to its soothing and protective nature. Studies on this plant
indicate the presence of several important compounds such as flavonoids, phenolic substances, anthocyanins, mucilage
polysaccharides, tannins, and sterols, which contribute to its therapeutic effects. Experimental findings suggest that Malva
sylvestris shows multiple biological effects, including antioxidant, anti-inflammatory, antimicrobial, and wound healing
properties, along with hepatoprotective, nephroprotective, laxative, antiviral actions. These effects are largely linked to its
phenolic and flavonoid components, as well as mucilage that supports tissue protection and recovery. This review
summarizes the chemical composition and biological effects of Malva sylvestris, focusing on its importance in traditional
use and its possible applications in modern therapy.
Keywords :
Malva sylvestris L., Phytochemistry, Antioxidant Activity, Anti-Inflammatory Activity, Antimicrobial Activity, Malvaceae.
References :
- Batiha GE-S, Tene ST, Teibo JO, Shaheen HM, Oluwatoba OS, Ayandeyi TK, et al. The phytochemical profiling, pharmacological activities, and safety of Malva sylvestris: a review. Naunyn Schmiedebergs Arch Pharmacol. 2023;396:421-440.
- Gasparetto JC, Martins CA, Hayashi SS, Otuky MF, Pontarolo R. Ethnobotanical and scientific aspects of Malva sylvestris L.: a millennial herbal medicine. J Pharm Pharmacol. 2012;64(2):172-189.
- Villani V, Di Marco G, Iacovelli F, Pietrucci D, Canini A, Gismondi A, et al. Profile and potential bioactivity of the miRNome and metabolome expressed in Malva sylvestris L. leaf and flower. BMC Plant Biol. 2023;23:439.
- Sharifi-Rad J, Melgar-Lalanne G, Hernández-Álvarez AJ, Taheri Y, Shaheen S, Kregiel D, et al. Malva species: insights on chemical composition and pharmacological applications. Phytother Res. 2019;33(3):546-567.
- Razavi SM, Zarrini G, Molavi G, Ghasemi G. Bioactivity of Malva sylvestris L., a medicinal plant from Iran. Iran J Basic Med Sci. 2011;14(6):574–579.
- Mousavi SM, Hashemi SA, Behbudi G, Mazraedoost S, Omidifar N, Gholami A, et al. A review on health benefits of Malva sylvestris L.: nutritional compounds, antioxidant and pharmacological activities. Evid Based Complement Alternat Med. 2021;2021:5548404.
- Massaro S, Sica J, Ghion G, Nadai C, Vincenzi S, Porcellato D, et al. Enhancing Malva sylvestris extract properties through lactic acid bacteria fermentation: impact on phytochemical profile and bioactivity. Food Prod Process Nutr. 2025;7:40.
- Irfan A, Imran M, Khalid M, et al. Phenolic and flavonoid contents in Malva sylvestris and exploration of active drugs as antioxidant and anti-COVID-19 by quantum chemical and molecular docking studies. J Saudi Chem Soc. 2021;25:101277.
- Memdueva N, Tzanova M, Yaneva Z, et al. Natural deep eutectic solvent-based extraction of Malva sylvestris L.: phytochemical content, antioxidant and antimicrobial potential. Separations. 2025;12(7):187.
- Effect of Artemisia absinthium and Malva sylvestris on antioxidant parameters and abomasal histopathology in lambs experimentally infected with Haemonchus contortus. Animals. 2021;11(2):462.
- Polysaccharide extraction from Malva sylvestris and its antioxidant activity. Int J Biol Macromol. 2013;60:427-436.
- Dehpour AR, et al. Analgesic and anti-inflammatory properties of hydroalcoholic extracts of Malva sylvestris flowers in a formalin-induced inflammation model in rats. Inflammopharmacology. 2020;28(3):631-640.
- Prudente AS, et al. Pre-clinical anti-inflammatory aspects of Malva sylvestris L. in TPA-induced mouse ear inflammation. European Journal of Pharmacology. 2013;715(1-3):286-294.
- Martins CAF, et al. Anti-inflammatory effect of Malva sylvestris leaf crude extracts on prostanoid production in LPS-induced RAW 264.7 cells. Molecules. 2017;22(11):1883.
- Arany I, et al. Reduction of cisplatin-induced inflammatory stress by hydroalcoholic extract of Malva sylvestris L. in a rat model. Journal of Ethnopharmacology. 2018.
- Fathi M, Ghane M, Pishkar L. Data on cytotoxic and antibacterial activity of synthesized Fe₃O₄ nanoparticles using Malva sylvestris. Data Brief. 2020;28:104929.
- Shadid KA, Shakya AK, Naik RR, Jaradat N, Farah HS, Shalan N, Khalaf NA, Oriquat GA. Phenolic content and antioxidant and antimicrobial activities of Malva sylvestris L. and related species leaves extract. J Chem. 2021;2021:8867400.
- Mahmoodi Esfanddarani H, Abbasi Kajani A, Bordbar AK. Green synthesis of silver nanoparticles using flower extract of Malva sylvestris and investigation of their antibacterial activity. IET Nanobiotechnology. 2018;12(4):412–416.
- Afshar M, Ravarian B, Zardast M, Moallem SA, Hasanpour Fard M, Valavi M. Evaluation of cutaneous wound healing activity of Malva sylvestris aqueous extract in BALB/c mice. Iran J Basic Med Sci. 2015;18(6):616–622.
- Sadeghi A, Hosseini SM, Mostafavi FS, et al. Effect of Malva sylvestris cream on burn injury and wounds in rats. PMC. 2015.
- Polyurethane/carboxymethylcellulose nanofibers containing Malva sylvestris extract for healing diabetic wounds: preparation, characterization, in vitro and in vivo studies. Mater Sci Eng C. 2020;114:111039.
- Bilayer nanofibers loaded with Malva sylvestris extract for enhanced wound healing applications. J Nanobiotechnol. 2024;22:16.
- Marouane W, Soussi A, Murat JC, Bezzine S, El Feki A. The protective effect of Malva sylvestris on rat kidney damaged by vanadium. Lipids Health Dis. 2011;10:65.
- Ben Saad A, Rjeibi I, Brahmi D, Smida A, Ncib S, Zouari N, et al. Malva sylvestris extract protects against lithium carbonate-induced kidney damage in rats. Biomed Pharmacother. 2016;84:1099–1107.
- Najafi H, Mohamadi Yarijani Z, Changizi-Ashtiyani S, Mansouri K, Modarresi M, Madani SH, et al. Protective effect of Malva sylvestris extract in ischemia-reperfusion induced acute kidney and remote liver injury. PLoS One. 2017;12(11):e0188270.
- Irfan A, Imran M, Khalid M, Ullah MS, Khalid N, Assiri MA, et al. Phenolic and flavonoid contents in Malva sylvestris and exploration of active drugs as antioxidant and anti-COVID-19 by molecular docking studies. Arab J Chem. 2021;14(8):103238.
- Jabri MA, Wannes D, Hajji N, Sakly M, Marzouki L, Sebai H. Role of laxative and antioxidant properties of Malva sylvestris leaves in constipation treatment. Biomed Pharmacother. 2017;89:29–35.
- Elsagh M, Fathi M, Shojaii A, Hashem-Dabaghian F, Ghods R. Efficacy of Malva sylvestris L. flowers aqueous extract for functional constipation: A placebo-controlled trial. Complement Ther Clin Pract. 2015;21(2):105–111.
- Ben Saad A, Rjeibi I, Brahmi D, Smida A, Ncib S, Zouari N, et al. Malva sylvestris extract protects against lithium carbonate-induced toxicity. Biomed Pharmacother. 2016;84:1099–1107.
Malva sylvestris L. is a medicinal plant from the Malvaceae family that is found across different regions,
including parts of Europe, North Africa, and Asia. It has been traditionally used for managing conditions related to
inflammation, digestion, and the respiratory system, mainly due to its soothing and protective nature. Studies on this plant
indicate the presence of several important compounds such as flavonoids, phenolic substances, anthocyanins, mucilage
polysaccharides, tannins, and sterols, which contribute to its therapeutic effects. Experimental findings suggest that Malva
sylvestris shows multiple biological effects, including antioxidant, anti-inflammatory, antimicrobial, and wound healing
properties, along with hepatoprotective, nephroprotective, laxative, antiviral actions. These effects are largely linked to its
phenolic and flavonoid components, as well as mucilage that supports tissue protection and recovery. This review
summarizes the chemical composition and biological effects of Malva sylvestris, focusing on its importance in traditional
use and its possible applications in modern therapy.
Keywords :
Malva sylvestris L., Phytochemistry, Antioxidant Activity, Anti-Inflammatory Activity, Antimicrobial Activity, Malvaceae.