Authors : Supraja.S. A.; Santhanalakshmi V.; Dr. D. P. Sivasakti Balan; R. J. Thayumanaswamy

Volume/Issue : Volume 11 - 2026, Issue 10 - October

Google Scholar : https://tinyurl.com/42tmzu8c

DOI : https://doi.org/10.38124/ijisrt/26Oct801

Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.

Abstract : Nanotechnology has emerged as a promising approach in modern medicine, particularly in targeted drug delivery and cancer treatment. Metal nanoparticles, such as gold, silver, and iron oxide nanoparticles, possess unique optical, magnetic, and chemical properties that make them useful in therapeutic and diagnostic applications. However, certain metal-based systems may face limitations, including potential toxicity, accumulation in organs, immune-system interactions, and difficulties in long-term clearance from the body. In contrast, protein-based nanoparticles, made from biocompatible materials such as albumin and gelatin, are being investigated as alternative drug-delivery systems. Their potential advantages include biodegradability, biocompatibility, and the ability to carry therapeutic substances. Nevertheless, their stability, drug-loading capacity, and effectiveness depend on their composition and design. This study aims to compare metal and protein-based nanoparticles in drug delivery by examining their mechanisms, advantages, limitations, safety concerns, and potential applications in cancer treatment. Through a review of existing scientific literature, the research seeks to understand whether protein-based nanoparticles offer meaningful advantages over metalbased and other systems and identify the challenges that must be addressed to improve the safety and effectiveness of nanomedicine. It also aims at promoting protein based nanoparticles for drug delivery in chemotherapy. The research is concluded by proposing protein-based nanoparticles as promising drug-delivery systems in cancer treatment, particularly due to their biocompatibility and ability to transport therapeutic agents.

Keywords : Protein Nanoparticles, Cancer Treatment, Drug Delivery, Biocompatibility, Toxicity, Biodegradability, Immunogenicity, Nanotechnology, Albumin, Abraxane.

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