Authors :
Dr. Shashank Babel; Dr. Olugbenga Akinsanya; Dr. Divya Babel; Dr. Vineet Vinay
Volume/Issue :
Volume 9 - 2024, Issue 7 - July
Google Scholar :
https://tinyurl.com/37nwhb89
Scribd :
https://tinyurl.com/445f4uxm
DOI :
https://doi.org/10.38124/ijisrt/IJISRT24JUL1658
Note : A published paper may take 4-5 working days from the publication date to appear in PlumX Metrics, Semantic Scholar, and ResearchGate.
Abstract :
This systematic review aimed to investigate the
efficacy of single visit and multiple visit regenerative
endodontics and compare the patient based clinical
outcome of permanent teeth treated with single visit &
multiple visit regenerative endodontic therapy. The
protocol was registered with Prospero registration code
CRD42024505225. A comprehensive search strategy was
performed in different databases—PubMed, CENTRAL,
ScienceDirect, CINAHL, ERIC and PsycINFO using
searching keywords and was limited to studies published
till January 2024 in English.
The Inclusion criteria for the study were randomized
clinical trial, prospective clinical studies, case Reports and
case Series. The search found 20 eligible articles, which
were included in the study. Risk of bias of clinical studies
was conducted using ROBINS-I tool and JBL tool was
used for quality assessment of case reports and case series
included.
The conclusions of our study concluded that in terms
of clinical outcome both the approaches presented success
of treatment with odds were greater with multiple visits
as compared to single visit REP but statistically there was
no difference between both the group. Radiographically
outcome - In terms of root width diameter post treatment,
single visit REPs were more successful as compared to
multiple visits but statistical difference was not present.
However, further research and emphasis should be given
on undertaking more clinical trials regeneration in
endodontics to provide proper results.
References :
- Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE, Chou R. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. International journal of surgery. 2021 Apr 1;88:105906.
- Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, Henry D, Altman DG, Ansari MT, Boutron I, Carpenter JR. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. bmj. 2016 Oct 12;355.
- Institute JB. The Joanna Briggs Institute Critical Appraisal Tools for Use in JBI Systematic Review: Checklists for Case Reports. The Joanna Briggs Institute; 2019.
- Institute JB. The Joanna Briggs Institute Critical Appraisal Tools for Use in JBI Systematic Reviews. Checklist for Case Series; 2017.
- Botero TM, Tang X, Gardner R, Hu JC, Boynton JR, Holland GR. Clinical evidence for regenerative endodontic procedures: immediate versus delayed induction? Journal of endodontics. 2017 Sep 1;43(9): S75-81.
- Cerqueira-Neto ACCL, Prado MC, Pereira AC, Oliveira ML, Vargas-Neto J, Gomes BPFA, et al. Clinical and Radiographic Outcomes of Regenerative Endodontic Procedures in Traumatized Immature Permanent Teeth: Interappointment Dressing or Single-Visit? J Endod. 2021;47(10):1598–608.
- Karam LE, El-batouty K, Nagy MM. Regenerative Ability of Immature Teeth with Necrotic Pulp in Single and Multiple Visits. Egypt J Hosp Med. 2023;92(1):6770–5.
- Shin SY, Albert JS, Mortman RE. One step pulp revascularization treatment of an immature permanent tooth with chronic apical abscess: A case report. Int Endod J. 2009;42(12):1118–26.
- Thomson A, Kahler B. Regenerative endodontics - Biologically-based treatment for immature permanent teeth: A case report and review of the literature. Aust Dent J. 2010;55(4):446–52.
- Chen X, Bao ZF, Liu Y, Liu M, Jin XQ, Xu X Bin. Regenerative endodontic treatment of an immature permanent tooth at an early stage of root development: A case report. J Endod 2013;39(5):719–22.
- Mccabe P. Revascularization of an immature tooth with apical periodontitis using a single visit protocol: A case report. Int Endod J. 2015;48(5):484–97.
- Chaniotis A. The use of a single-step regenerative approach for the treatment of a replanted mandibular central incisor with severe resorption. Int Endod J. 2016;49(8):802–12.
- Miltiadous MEA, Floratos SG. Regenerative endodontic treatment as a retreatment option for a tooth with open apex - A case report. Braz Dent J. 2015;26(5):552–6.
- Llaquet M, Mercadé M, Plotino G. Procedura di rigenerazione endodontica: revisione della letteratura e caso clinico di un incisivo centrale immaturo. G Ital Endod. 2017;31(2):65–72.
- Kaval ME, Güneri P, Çalışkan MK. Regenerative endodontic treatment of perforated internal root resorption: a case report. Int Endod J. 2018;51(1):128–37.
- Alsofi L. Regenerative endodontics for upper permanent central incisors after traumatic injury: Case report with a 3-year follow-up. J Contemp Dent Pract. 2019;20(8):974–7.
- Alasqah M, Khan SIR, Alfouzan K, Jamleh A. Regenerative Endodontic Management of an Immature Molar Using Calcium Hydroxide and Triple Antibiotic Paste: A Two-Year Follow-Up. Case Rep Dent. 2020;2020.
- Turk T, Cicconetti A, Di Nardo D, Gabriele M, Coppola S, Bhandi S, et al. Nonsurgical Retreatment Using Regenerative Endodontic Protocols: A Case Report. J Contemp Dent Pract. 2020;21(11):1275–8.
- Abdel Hafiz Abdel Rahim AS, Abdelgawad F, Abd Alsamed AM, Moheb DM, Wahab El-Dokky NA. Case Report: Single visit photo-activated disinfection in regenerative endodontics. F1000Research. 2020;8:1–15.
- Lenzi R, Hernández SR, Alves FR, Ro IN. Regenerative endodontic therapy for management of an immature permanent tooth with recurrent post-treatment apical periodontitis: A case report. Journal of International Society of Preventive and Community Dentistry. 2022 Jul 1;12(4):468-73.
- Alsharqawi N, Austah O. Single-visit regenerative endodontic procedure of necrotic immature lower permanent molar with acute apical abscess. Saudi Endod J. 2023;13(2):204.
- Topçuoğlu G, Topçuoğlu HS. Regenerative Endodontic Therapy in a Single Visit Using Platelet-rich Plasma and Biodentine in Necrotic and Asymptomatic Immature Molar Teeth: A Report of 3 Cases. J Endod. 2016;42(9):1344–6.
- Yoshpe M, Einy S, Ruparel N, Lin S, Kaufman AY. Regenerative Endodontics: A Potential Solution for External Root Resorption (Case Series). J Endod 2020;46(2):192–9.
- Sharaf P, Sherif R, Zaazou A, Hafez S, ElBackly R. Single Visit Regenerative Endodontic Treatment (Ret) in Traumatized Necrotic Immature Permanent Teeth: a Report of Three Cases. Alexandria Dent J. 2023;48(3):172–9.
- 25. Rahul M, Lokade A, Tewari N, Mathur V, Agarwal D, Goel S, Keshari P, Sharma S, Bansal K. Effect of Intracanal Scaffolds on the Success Outcomes of Regenerative Endodontic Therapy-A Systematic Review and Network Meta-analysis. Journal of Endodontics. 2023 Feb 1;49(2):110-28.
This systematic review aimed to investigate the
efficacy of single visit and multiple visit regenerative
endodontics and compare the patient based clinical
outcome of permanent teeth treated with single visit &
multiple visit regenerative endodontic therapy. The
protocol was registered with Prospero registration code
CRD42024505225. A comprehensive search strategy was
performed in different databases—PubMed, CENTRAL,
ScienceDirect, CINAHL, ERIC and PsycINFO using
searching keywords and was limited to studies published
till January 2024 in English.
The Inclusion criteria for the study were randomized
clinical trial, prospective clinical studies, case Reports and
case Series. The search found 20 eligible articles, which
were included in the study. Risk of bias of clinical studies
was conducted using ROBINS-I tool and JBL tool was
used for quality assessment of case reports and case series
included.
The conclusions of our study concluded that in terms
of clinical outcome both the approaches presented success
of treatment with odds were greater with multiple visits
as compared to single visit REP but statistically there was
no difference between both the group. Radiographically
outcome - In terms of root width diameter post treatment,
single visit REPs were more successful as compared to
multiple visits but statistical difference was not present.
However, further research and emphasis should be given
on undertaking more clinical trials regeneration in
endodontics to provide proper results.