Authors : Miguel A. Fernandez; Divina Maris Mande; Angel Ventura; Albert Jommel De Leon; Gecelene C. Estorico

Volume/Issue : Volume 9 - 2024, Issue 11 - November

Google Scholar : https://tinyurl.com/mvma27p

Scribd : https://tinyurl.com/49kda9er

DOI : https://doi.org/10.5281/zenodo.14329558

Abstract : Cordyceps sinensis, a revered traditional Chinese medicine, has garnered significant attention for its diverse pharmacological properties. This comprehensive review delves into its potential health benefits, focusing on its bioactive compounds, clinical efficacy, and underlying mechanisms of action. Key findings reveal its anti-cancer properties, including anti- proliferative, anti-metastatic, and immune-boosting effects against various cancer cell lines. Additionally, its anti-inflammatory properties are evident in its ability to suppress inflammation by regulating key signaling pathways and reducing oxidative stress. Furthermore, Cordyceps sinensis exhibits anti-tumor activity, particularly through compounds like cordycepin, which induce apoptosis and cell cycle arrest in cancer cells. The anti-fibrotic potential is highlighted by its capacity to mitigate inflammation, reduce fibrosis, and regulate key proteins involved in tissue repair. Cellular protection against oxidative damage is attributed to the antioxidant properties of its polysaccharides and other bioactive compounds. Additionally, its anti-proliferative effects are reflected in the inhibition of cell growth and proliferation. While these findings are promising and encouraging, more extensive clinical research is required to completely clarify its effectiveness and safety in human populations. However, Cordyceps sinensis offers a promising supplemental or alternative medicine and a natural approach to a number of medical disorders.

Keywords : Medicinal Mushroom, Natural Remedy, Bioactive Compounds, Pharmacological Properties, Traditional Chinese Medicine.

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