Authors :
Diayanti Tenti Lestari; Mohammad Saiful Ardhi; Mudjiani Basuki
Volume/Issue :
Volume 6 - 2021, Issue 10 - October
Google Scholar :
http://bitly.ws/gu88
Scribd :
https://bit.ly/3CtgcAX
Abstract :
Background and Purpose: Based on the high
mortality and morbidity rate, stroke is included as a
major public health disease. The inflammatory response
of stroke is mediated by the immune system. In ischemic
stroke, increased expression of various cytokines and
chemokines causes leukocyte infiltration into ischemic
tissue. It has considered as the main mediator of the
response of inflammation and endothelial destruction.
Leukocytes assessment upon hospitalisation is expected
to define the specific treatment of stroke patients
efficiently. This study aimed to identify the correlation
between leukocyte level upon hospitalized and clinical
outcomes of mild and moderate acute ischemic stroke in
neurologic inpatients care at Dr. Soetomo Hospital.
Method: A retrospective cross-sectional method was
used in this study. Sample data were collected from the
stroke registry in the neurologic room at Dr. Soetomo
hospital from January to March 2019. Leukocyte levels
were collected upon hospitalisation and the clinical
outcome of stroke. The data were assessed using the
National Institutes of Health Stroke Scale (NIHSS) upon
discharge. Data were analysed using SPSS version 24
with p<0.05 as a significant value. Result: From the
stroke registry data, it was found that 55 subjects have
fulfilled the criteria for this study. Patients with a mild
deficit NIHSS clinical outcome with normal leukocyte
level showed in 23 (82%) patients, while there were 5
(18%) patients who had leucocytosis. Patients with
moderate deficit NIHSS clinical outcomes showed
normal leukocyte values in 14 (52%) patients and as
many as 13 (48%) patients showed leucocytosis. The chisquare test resulted in a significant value with p-value =
0.017 (RO: 4.27 (95% CI = 1.25-14.56)). Conclusion:
There is a correlation between leukocyte values at
baseline and clinical outcome of acute ischemic stroke
with mild deficits and moderate deficits as assessed by
the NIHSS.
Keywords :
Leukocytes; Ischemic Stroke; Clinical Outcome; NIHSS; Mild and Moderate Deficits.
Background and Purpose: Based on the high
mortality and morbidity rate, stroke is included as a
major public health disease. The inflammatory response
of stroke is mediated by the immune system. In ischemic
stroke, increased expression of various cytokines and
chemokines causes leukocyte infiltration into ischemic
tissue. It has considered as the main mediator of the
response of inflammation and endothelial destruction.
Leukocytes assessment upon hospitalisation is expected
to define the specific treatment of stroke patients
efficiently. This study aimed to identify the correlation
between leukocyte level upon hospitalized and clinical
outcomes of mild and moderate acute ischemic stroke in
neurologic inpatients care at Dr. Soetomo Hospital.
Method: A retrospective cross-sectional method was
used in this study. Sample data were collected from the
stroke registry in the neurologic room at Dr. Soetomo
hospital from January to March 2019. Leukocyte levels
were collected upon hospitalisation and the clinical
outcome of stroke. The data were assessed using the
National Institutes of Health Stroke Scale (NIHSS) upon
discharge. Data were analysed using SPSS version 24
with p<0.05 as a significant value. Result: From the
stroke registry data, it was found that 55 subjects have
fulfilled the criteria for this study. Patients with a mild
deficit NIHSS clinical outcome with normal leukocyte
level showed in 23 (82%) patients, while there were 5
(18%) patients who had leucocytosis. Patients with
moderate deficit NIHSS clinical outcomes showed
normal leukocyte values in 14 (52%) patients and as
many as 13 (48%) patients showed leucocytosis. The chisquare test resulted in a significant value with p-value =
0.017 (RO: 4.27 (95% CI = 1.25-14.56)). Conclusion:
There is a correlation between leukocyte values at
baseline and clinical outcome of acute ischemic stroke
with mild deficits and moderate deficits as assessed by
the NIHSS.
Keywords :
Leukocytes; Ischemic Stroke; Clinical Outcome; NIHSS; Mild and Moderate Deficits.
