Epicardial adipose tissue (EAT) is
splanchnopleuric mesoderm-derived tissue that
communicates locally with coronary vessels and
myocardium via paracrine and vasocrine routes. This
tissue secretes pro-atherogenic and pro-inflammatory
cytokines that affect cardiac function. Some studies
found a significant relationship between EAT thickness
and coronary artery disease (CAD).
Methods: This analytical, observational study aimed to
assess the relationship between EAT thickness and
coronary artery stenosis lesion severity in CAD patients
of RSUP HAM. EAT thickness was measured using
Doppler echocardiography by a cardiologist, while the
severity of coronary artery stenosis lesion was
determined by SYNTAX score. Bivariate analysis and Ttest were used to analyze the difference between CAD
with significant lesion and nonsignificant groups. ROC
(Receiver Operating Curve) analysis was used to
determine the cut-off value of EAT thickness that could
predict the severity of the lesion.
Results: All 79 patients (39 CAD with significant lesion
and 39 nonsignificant lesion) was dominated by male
(57,6% and 42,4%). Diastole and systole EAT thickness
of ≥2,75 mm, and ≥5,5 mm could predict CAD diagnoses.
These cut-off points also had six times higher risk of
developing significant coronary artery lesion, which was
described by a SYNTAX score of > 22 [each had OR of
6,000 (IK95% 1,296-27,769)]
Conclusion: EAT thickness measurement using
echocardiography could differentiate CAD with
signifincant lesion with non-significant patients, and it
also could predict the severity of coronary artery lesions
in CAD patient
Keywords : Epicardial Adipose Tissue, SYNTAX, CAD.