Correlation of Interferon Gamma (IFN-γ), Platelet to Lymphocyte Ratio (PLR), and Mortality of Covid-19 Patients


Authors : Giovanni Antonio Wijanto; Agustin Iskandar; Catur Suci Sutrisnani

Volume/Issue : Volume 8 - 2023, Issue 7 - July

Google Scholar : https://bit.ly/3TmGbDi

Scribd : https://tinyurl.com/5n7e3abc

DOI : https://doi.org/10.5281/zenodo.8210443

Abstract : Severe and critical cases of COVID-19 can occur due to a cytokine storm involving many inflammatory mediators including platelets, lymphocytes, cytokines and chemokines. Platelets are one of the factors that affect inflammation indirectly, while lymphocytes will be greatly affected in the state of COVID-19 where both can decrease due to various reasons. One of the cytokines involved in COVID-19 is IFN-γ which can trigger other cytokines in a cytokine storm in COVID-19 and various other conditions related to COVID-19. In COVID-19, there is also an increase in Platelet-To- Lymphocyte Ratio (PLR) and IFN-γ. The increase in PLR and IFN-γ is expected to be one of the means of predicting patient outcomes. To see the correlation between PLR, IFN-γ, and mortality, we conducted a logistic regression test, path analysis, and survival analysis. There were no significant differences in IFN-γ levels, PLR, and length of treatment between survivor and non-survivor patients. In addition, there were no significant differences in all characteristics of subjects with mild-moderate, severe, and very severe severity. It can be concluded that IFN-γ and PLR were not correlated with each other and when combined, IFN-γ and PLR showed no difference in prognosis obtained from survival analysis.

Keywords : COVID-19, Interferon Gamma, Platelet-To- Lymphocyte Ratio, Mortality.

Severe and critical cases of COVID-19 can occur due to a cytokine storm involving many inflammatory mediators including platelets, lymphocytes, cytokines and chemokines. Platelets are one of the factors that affect inflammation indirectly, while lymphocytes will be greatly affected in the state of COVID-19 where both can decrease due to various reasons. One of the cytokines involved in COVID-19 is IFN-γ which can trigger other cytokines in a cytokine storm in COVID-19 and various other conditions related to COVID-19. In COVID-19, there is also an increase in Platelet-To- Lymphocyte Ratio (PLR) and IFN-γ. The increase in PLR and IFN-γ is expected to be one of the means of predicting patient outcomes. To see the correlation between PLR, IFN-γ, and mortality, we conducted a logistic regression test, path analysis, and survival analysis. There were no significant differences in IFN-γ levels, PLR, and length of treatment between survivor and non-survivor patients. In addition, there were no significant differences in all characteristics of subjects with mild-moderate, severe, and very severe severity. It can be concluded that IFN-γ and PLR were not correlated with each other and when combined, IFN-γ and PLR showed no difference in prognosis obtained from survival analysis.

Keywords : COVID-19, Interferon Gamma, Platelet-To- Lymphocyte Ratio, Mortality.

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