Authors :
Kamalakannan M; Dr. Dayanandan
Volume/Issue :
Volume 5 - 2020, Issue 11 - November
Google Scholar :
http://bitly.ws/9nMw
Scribd :
https://bit.ly/3lG2u5r
Abstract :
Stroke is the second leading cause of death all
around the world. There is no specific investigations to
assess the prognosis of patients with acute stroke as yet.
A variety of enzymes like CPK are produced in the brain
and any injury like stroke to brain tissue could result in
an increase in the levels of these enzymes. The test not
usually considered in stroke is CPK, which is though a
nonspecific, although same degree of raised CPK levels
may have prognostic implications. The aim of this study
was to highlight the importance of using CPK in acute
stroke as a tool to predict the severity and its role in
assessing worsening prognosis with rising level.
1. To study the creatine phosphokinase levels (CPK
levels) in stroke patients
2. To determine the association between CPK levels and
the severity of acute stroke.
Materials And Method:
A prospective study was conducted at Saveetha
medical college hospital, Thandalam, Chennai. It
comprises 50 stroke patients who were admitted at the
hospital(sample size=50). The Study period was from
January 2020 to March 2020 (3 months). The Study
population was Acute stroke patients. The study subjects
were sent for laboratory test of Serum creatine
phosphokinase (CPK total). Clinical examination was
conducted on all study subjects. Modified rankin
scale(mRS) was employed to assess the severity of acute
stroke.
A total of 50 stroke patients took part in this study.
The study showed that 36 had ischemic stroke(72%) and
14 had hemorrhagic stroke(28%). The number of
patients who are diabetic is 31(62%)and hypertensive is
29(58%) which are all the risk factors for stroke.On
calculating the serum Creatine phosphokinase levels ,
the mean was 239.75 IU/L. mRS score was 4 for 19 of the
study subjects. With increasing severity of acute stroke
in study subjects, there has been persistent increase in
Serum CPK levels.
It is concluded that there has been presence of
association between the creatine phosphokinase levels
and the severity of acute stroke through this prospective
study. Serum levels of CPK were found to be increased
in acute stroke patients signifying the need of calculating
the CPK levels for assessing the prognosis of acute
stroke.
Keywords :
Creatine Phosphokinase, Acute Stroke , Modified Rankin Scale
Stroke is the second leading cause of death all
around the world. There is no specific investigations to
assess the prognosis of patients with acute stroke as yet.
A variety of enzymes like CPK are produced in the brain
and any injury like stroke to brain tissue could result in
an increase in the levels of these enzymes. The test not
usually considered in stroke is CPK, which is though a
nonspecific, although same degree of raised CPK levels
may have prognostic implications. The aim of this study
was to highlight the importance of using CPK in acute
stroke as a tool to predict the severity and its role in
assessing worsening prognosis with rising level.
1. To study the creatine phosphokinase levels (CPK
levels) in stroke patients
2. To determine the association between CPK levels and
the severity of acute stroke.
Materials And Method:
A prospective study was conducted at Saveetha
medical college hospital, Thandalam, Chennai. It
comprises 50 stroke patients who were admitted at the
hospital(sample size=50). The Study period was from
January 2020 to March 2020 (3 months). The Study
population was Acute stroke patients. The study subjects
were sent for laboratory test of Serum creatine
phosphokinase (CPK total). Clinical examination was
conducted on all study subjects. Modified rankin
scale(mRS) was employed to assess the severity of acute
stroke.
A total of 50 stroke patients took part in this study.
The study showed that 36 had ischemic stroke(72%) and
14 had hemorrhagic stroke(28%). The number of
patients who are diabetic is 31(62%)and hypertensive is
29(58%) which are all the risk factors for stroke.On
calculating the serum Creatine phosphokinase levels ,
the mean was 239.75 IU/L. mRS score was 4 for 19 of the
study subjects. With increasing severity of acute stroke
in study subjects, there has been persistent increase in
Serum CPK levels.
It is concluded that there has been presence of
association between the creatine phosphokinase levels
and the severity of acute stroke through this prospective
study. Serum levels of CPK were found to be increased
in acute stroke patients signifying the need of calculating
the CPK levels for assessing the prognosis of acute
stroke.
Keywords :
Creatine Phosphokinase, Acute Stroke , Modified Rankin Scale
