Stroke is the second leading cause of death all around the world. There is no specific investigations to assess the prognosis of patients with acute stroke as yet. A variety of enzymes like CPK are produced in the brain and any injury like stroke to brain tissue could result in an increase in the levels of these enzymes. The test not usually considered in stroke is CPK, which is though a nonspecific, although same degree of raised CPK levels may have prognostic implications. The aim of this study was to highlight the importance of using CPK in acute stroke as a tool to predict the severity and its role in assessing worsening prognosis with rising level. 1. To study the creatine phosphokinase levels (CPK levels) in stroke patients 2. To determine the association between CPK levels and the severity of acute stroke.  Materials And Method: A prospective study was conducted at Saveetha medical college hospital, Thandalam, Chennai. It comprises 50 stroke patients who were admitted at the hospital(sample size=50). The Study period was from January 2020 to March 2020 (3 months). The Study population was Acute stroke patients. The study subjects were sent for laboratory test of Serum creatine phosphokinase (CPK total). Clinical examination was conducted on all study subjects. Modified rankin scale(mRS) was employed to assess the severity of acute stroke. A total of 50 stroke patients took part in this study. The study showed that 36 had ischemic stroke(72%) and 14 had hemorrhagic stroke(28%). The number of patients who are diabetic is 31(62%)and hypertensive is 29(58%) which are all the risk factors for stroke.On calculating the serum Creatine phosphokinase levels , the mean was 239.75 IU/L. mRS score was 4 for 19 of the study subjects. With increasing severity of acute stroke in study subjects, there has been persistent increase in Serum CPK levels. It is concluded that there has been presence of association between the creatine phosphokinase levels and the severity of acute stroke through this prospective study. Serum levels of CPK were found to be increased in acute stroke patients signifying the need of calculating the CPK levels for assessing the prognosis of acute stroke.

Keywords : Creatine Phosphokinase, Acute Stroke , Modified Rankin Scale